Generation of two induced pluripotent stem cell lines to model and investigate diseases affecting Pacific Islanders

被引：0
|
作者：
Zhang, Angela [1 ,2 ,3 ]
Jahng, James W. S. [1 ,4 ]
V. Guevara, Julio [1 ]
Yan, Christopher D. [5 ]
McConnell, Michael, V [1 ]
Wu, Joseph C. [1 ,4 ]
机构：
[1] Stanford Cardiovasc Inst, Stanford, CA 94305 USA
[2] Stanford Univ, Sch Med, Dept Genet, Stanford, CA 94305 USA
[3] Stanford Univ, Sch Engn, Dept Comp Sci, Stanford, CA 94305 USA
[4] Dept Med, Div Cardiovasc Med, Palo Alto, CA 94304 USA
[5] Greenstone Biosci, Palo Alto, CA 94304 USA
来源：
STEM CELL RESEARCH | 2025年 / 83卷
基金：
美国国家卫生研究院;
关键词：
Stem cells; Disease modeling; Drug screening; Pacific Islanders;
D O I：
10.1016/j.scr.2025.103668
中图分类号：
Q813 [细胞工程];
学科分类号：
摘要：
Pacific Islanders (PI) comprise only 0.4% of the US population, yet they have amongst the highest prevalence of diseases. They are historically underreported in medical literature and underrepresented in clinical investigation. Increased representation in clinical datasets can mitigate disparities and address differential health outcomes. In recent years, induced pluripotent stem cells (iPSCs) have become a popular platform for disease and drug investigation. Here, we generate two iPSC lines from the peripheral blood mononuclear cells (PBMCs) of healthy PI patients. We demonstrate that the lines exhibit normal morphology and karyotypes, robust expression of pluripotent markers, and the capacity for trilineage differentiation.
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页数：4
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