HISTORICAL USE OF MEDICINAL PLANTS AND FUTURE POTENTIAL: FROM PHYTOTHERAPY TO PHYTOCHEMICALS

被引：1

作者：

Claro, A. E. ^{[1
,2
,3
]}

Palanza, C. ^{[4
]}

Mazza, M. ^{[5
]}

Schuenemann, G. e u muti ^{[6
]}

Rigoni, M. ^{[1
]}

Pontecorvi, A. ^{[7
]}

Janiri, L. ^{[5
]}

Pitocco, D. ^{[2
,3
]}

Muti, P. ^{[1
]}

机构：

[1] Univ Milan, Dept Biomed Surg & Dent Sci, Milan, Italy

[2] Fdn Policlin Univ Agostino Gemelli IRCCS, Dept Med & Surg Sci, Diabet Care Unit, Rome, Italy

[3] Univ Cattolica Sacro Cuore, Rome, Italy

[4] Sapienza Univ Rome, Dept Environm Biol, Rome, Italy

[5] Univ Cattolica Sacro Cuore, Fdn Policlin Univ Agostino Gemelli IRCCS, Dept Neurosci, Unit Psychiat, Rome, Italy

[6] McMaster Univ, Hlth Res Methods Evidence & Impact Dept, Hamilton, ON, Canada

[7] Univ Cattolica Sacro Cuore, Fdn Policlin Univ Agostino Gemelli IRCCS, Dept Endocrine Metab & Dermorheumatol, Div Endocrinol, Rome, Italy

来源：

ANNALI DI BOTANICA | 2024年 / 14卷

关键词：

PHYTOCHEMICALS; PHYTOTHERAPY; ANTINEOPLASTIC AGENTS; HYPOGLYCEMIC AGENTS; ONE HEALTH; MEDICINE CHINESE TRADITIONAL; TRADITIONAL CHINESE MEDICINE; NATURAL-PRODUCTS; CAROLUS LINNAEUS; HERBAL MEDICINE; DISCOVERY; BIGUANIDES; ALKALOIDS; SCIENCE; CANCER; CURARE;

D O I：

10.13133/2239-3129/18564

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

Since prehistoric times, humans have understood that plants possessed healing properties. The knowledge of herbal medicine has been accumulated for millennia by traditional healers and has been passed down from generation to generation. Phytotherapy was used as the main therapy until the 18th century. Even today, between 40% and 80% of pharmaceuticals are phytochemicals or of plant origin and many of these have significantly changed or are still changing medical therapy. Most people in the world are or have been treated with phytochemicals or drugs derived from phytochemicals. Examples include antineoplastic agents (vinblastine, vincristine, etoposide, teniposide, paclitaxel, irinotecan, topotecan), antibiotics and antivirals (cephalosporins and oseltamivir), antiparasitic drugs (quinine and artemisinin), Intensive Care Unit (ICU) drugs (morphine, neuromuscular blockers, ephedrine), cardiovascular drugs (digoxin, quinidine, atropine, reserpine), antidiabetics (metformin), and many others. Many of these agents are included in the WHO list of essential medicines. Plant-derived medicines have changed human history, contributing fundamentally to the survival and improvement of our species' life expectancy. Phytochemicals, derived from interactions between plants and the environment, are substances often created over millennia. If humans had not drawn on these substances for medical therapy, they probably would never have been able to produce substances so complex and effective in treating disease. Since knowledge of the healing properties of plants is present in traditional medicines, ancient manuscripts should be studied as potential sources of contemporary pharmacotherapy. Unfortunately, in recent years several trends have started to threaten biodiversity and consequently also phytochemical resources. From this perspective, the "One Health" approach is further justified and could also encourage the discovery of new revolutionary phytochemicals.

引用

页码：127 / 156

页数：30

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