Carnosic acid prevents heat stress-induced oxidative damage by regulating heat-shock proteins and apoptotic proteins in mouse testis

被引：1

作者：

Liu, Sirui ^{[1
]}

Liang, Wanqing ^{[1
]}

Liu, Yinkun ^{[1
]}

Wan, Shuangshuang ^{[1
]}

Tang, Shu ^{[1
]}

机构：

[1] Nanjing Agr Univ, Coll Vet Med, 1 Weigang, Nanjing 210095, Peoples R China

来源：

BIOLOGICAL CHEMISTRY | 2024年

基金：

中国国家自然科学基金;

关键词：

carnosic acid; Hsp70; heat stress; apoptosis; knockout mice; INJURY; MILD;

D O I：

10.1515/hsz-2023-0374

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Heat stress impacts male reproduction in animal husbandry. Carnosic acid (CA), a potent antioxidant, mitigates oxidative stress and apoptosis. alpha B-crystallin, a small heat shock protein, regulates apoptosis and oxidative stress. This study examines the protective effects of CA on the testis in wild-type and alpha B-crystallin knockout mice under heat stress. CA pretreatment increased testosterone levels and preserved testicular structure in wild-type mice, but no changes in knockout mice. CA reduced Hsp27, Hsp70, and cleaved caspase-3 levels, while knockout mice showed increased cleaved caspase-3. These results suggest that CA protects the testis by modulating heat shock and apoptosis-related proteins.

引用

页码：745 / 749

页数：5

共 29 条

[1] Heat stress response of somatic cells in the testis [J].

Aldahhan, Rashid A. ;

Stanton, Peter G. .

MOLECULAR AND CELLULAR ENDOCRINOLOGY, 2021, 527

[2] Caspase-3: Structure, function, and biotechnological aspects [J].

Asadi, Marzieh ;

Taghizadeh, Saeed ;

Kaviani, Elina ;

Vakili, Omid ;

Taheri-Anganeh, Mortaza ;

Tahamtan, Mahshid ;

Savardashtaki, Amir .

BIOTECHNOLOGY AND APPLIED BIOCHEMISTRY, 2022, 69 (04) :1633-1645

[3] Carnosic acid [J].

Birtic, Simona ;

Dussort, Pierre ;

Pierre, Francois-Xavier ;

Bily, Antoine C. ;

Roller, Marc .

PHYTOCHEMISTRY, 2015, 115 :9-19

[4] Antioxidant Properties of the Mung Bean Flavonoids on Alleviating Heat Stress [J].

Cao, Dongdong ;

Li, He ;

Yi, Jianyong ;

Zhang, Jingjing ;

Che, Huilian ;

Cao, Jiankang ;

Yang, Liu ;

Zhu, Chunqiu ;

Jiang, Weibo .

PLOS ONE, 2011, 6 (06)

[5] Impacts of heat stress on immune responses and oxidative stress in farm animals and nutritional strategies for amelioration [J].

Chauhan, Surinder S. ;

Rashamol, V. P. ;

Bagath, M. ;

Sejian, Veerasamy ;

Dunshea, Frank R. .

INTERNATIONAL JOURNAL OF BIOMETEOROLOGY, 2021, 65 (07) :1231-1244

[6] The multiple roles of LDH in cancer [J].

Claps, Giuseppina ;

Faouzi, Sara ;

Quidville, Virginie ;

Chehade, Feras ;

Shen, Shensi ;

Vagner, Stephan ;

Robert, Caroline .

NATURE REVIEWS CLINICAL ONCOLOGY, 2022, 19 (12) :749-762

[7] Maintenance of muscle mass in adult male mice is independent of testosterone [J].

Davidyan, Arik ;

Pathak, Suraj ;

Baar, Keith ;

Bodine, Sue C. .

PLOS ONE, 2021, 16 (03)

[8] Heat shock proteins: Biological functions, pathological roles, and therapeutic opportunities [J].

Hu, Chen ;

Yang, Jing ;

Qi, Ziping ;

Wu, Hong ;

Wang, Beilei ;

Zou, Fengming ;

Mei, Husheng ;

Liu, Jing ;

Wang, Wenchao ;

Liu, Qingsong .

MEDCOMM, 2022, 3 (03)

[9] Carnosic acid suppresses colon tumor formation in association with antiadipogenic activity [J].

Kim, Yun-Ji ;

Kim, Jong-Sang ;

Seo, Young Rok ;

Park, Jung Han Yoon ;

Choi, Myung-Sook ;

Sung, Mi-Kyung .

MOLECULAR NUTRITION & FOOD RESEARCH, 2014, 58 (12) :2274-2285

[10] Molecular and biochemical evidence on the protective effects of embelin and carnosic acid in isoproterenol-induced acute myocardial injury in rats [J].

Kocak, Cengiz ;

Kocak, Fatma Emel ;

Akcilar, Raziye ;

Isiklar, Ozben Ozden ;

Kocak, Havva ;

Bayat, Zeynep ;

Simsek, Hasan ;

Taser, Figen ;

Altuntas, Irfan .

LIFE SCIENCES, 2016, 147 :15-23

← 1 2 3 →