Human endogenous retroviruses and exogenous viral infections

被引：5
作者：
Bao, Chenxuan [1 ]
Gao, Qing [1 ]
Xiang, Huayuan [1 ]
Shen, Yuxuan [2 ]
Chen, Qiaoqiao [1 ]
Gao, Qianqian [1 ]
Cao, Yuanfei [1 ]
Zhang, Mengyu [1 ]
He, Wenyuan [1 ]
Mao, Lingxiang [1 ]
机构：
[1] Jiangsu Univ, Affiliated Kunshan Hosp, Dept Lab Med, Kunshan, Jiangsu, Peoples R China
[2] Yangzhou Univ, Med Coll, Yangzhou, Jiangsu, Peoples R China
来源：
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY | 2024年 / 14卷
基金：
中国国家自然科学基金;
关键词：
human endogenous retroviruses (HERVs); virus infection; antiviral immunity; active immunity; HERV-K; HERV-W; T-CELL RESPONSES; IMMUNODEFICIENCY-VIRUS TYPE-1; LONG TERMINAL REPEAT; HERV-K; REVERSE-TRANSCRIPTASE; DNA-SEQUENCES; CUTTING EDGE; HIV-1; EXPRESSION; PROTEIN;
D O I：
10.3389/fcimb.2024.1439292
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
The human genome harbors many endogenous retroviral elements, known as human endogenous retroviruses (HERVs), which have been integrated into the genome during evolution due to infections by exogenous retroviruses. Accounting for up to 8% of the human genome, HERVs are tightly regulated by the host and are implicated in various physiological and pathological processes. Aberrant expression of HERVs has been observed in numerous studies on exogenous viral infections. In this review, we focus on elucidating the potential roles of HERVs during various exogenous viral infections and further discuss their implications in antiviral immunity.
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页数：13
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