UniProt: the Universal Protein Knowledgebase in 2025

被引：191

作者：

Bateman, Alex ^{[1
]}

Martin, Maria-Jesus ^{[1
]}

Orchard, Sandra ^{[1
]}

Magrane, Michele ^{[1
]}

Adesina, Aduragbemi ^{[1
]}

Ahmad, Shadab ^{[1
]}

Bowler-Barnett, Emily H. ^{[1
]}

Bye-A-Jee, Hema ^{[1
]}

Carpentier, David ^{[1
]}

Denny, Paul ^{[1
]}

Fan, Jun ^{[1
]}

Garmiri, Penelope ^{[1
]}

Gonzales, Leonardo Jose da Costa ^{[1
]}

Hussein, Abdulrahman ^{[1
]}

Ignatchenko, Alexandr ^{[1
]}

Insana, Giuseppe ^{[1
]}

Ishtiaq, Rizwan ^{[1
]}

Joshi, Vishal ^{[1
]}

Jyothi, Dushyanth ^{[1
]}

Kandasaamy, Swaathi ^{[1
]}

Lock, Antonia ^{[1
]}

Luciani, Aurelien ^{[1
]}

Luo, Jie ^{[1
]}

Lussi, Yvonne ^{[1
]}

Marin, Juan Sebastian Martinez ^{[1
]}

Raposo, Pedro ^{[1
]}

Rice, Daniel L. ^{[1
]}

Santos, Rafael ^{[1
]}

Speretta, Elena ^{[1
]}

Stephenson, James ^{[1
]}

Totoo, Prabhat ^{[1
]}

Tyagi, Nidhi ^{[1
]}

Urakova, Nadya ^{[1
]}

Vasudev, Preethi ^{[1
]}

Warner, Kate ^{[1
]}

Wijerathne, Supun ^{[1
]}

Yu, Conny Wing-Heng ^{[1
]}

Zaru, Rossana ^{[1
]}

Bridge, Alan J. ^{[3
]}

Aimo, Lucila ^{[3
]}

Argoud-Puy, Ghislaine ^{[3
]}

Auchincloss, Andrea H. ^{[3
]}

Axelsen, Kristian B. ^{[3
]}

Bansal, Parit ^{[3
]}

Baratin, Delphine ^{[3
]}

Batista Neto, Teresa M. ^{[3
]}

Blatter, Marie-Claude ^{[3
]}

Bolleman, Jerven T. ^{[3
]}

Boutet, Emmanuel ^{[3
]}

Breuza, Lionel ^{[3
]}

机构：

[1] European Bioinformat Inst EMBL EBI, European Mol Biol Lab, Wellcome Genome Campus, Hinxton CB10 1SD, England

[2] Ctr Med Univ Geneva, SIB Swiss Inst Bioinformat, 1 Rue Michel Servet, CH-1211 Geneva 4, Switzerland

[3] SIB Swiss Inst Bioinformat, Geneva, Switzerland

[4] Prot Informat Resource, Washington, DC USA

来源：

NUCLEIC ACIDS RESEARCH | 2024年 / 52卷 / D1期

基金：

美国国家卫生研究院; 英国生物技术与生命科学研究理事会; 欧盟地平线“2020”; 美国国家科学基金会;

关键词：

ANNOTATION; RESOURCE; DATABASE; UPDATE;

D O I：

10.1093/nar/gkae1010

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The aim of the UniProt Knowledgebase (UniProtKB; https://www.uniprot.org/) is to provide users with a comprehensive, high-quality and freely accessible set of protein sequences annotated with functional information. In this publication, we describe ongoing changes to our production pipeline to limit the sequences available in UniProtKB to high-quality, non-redundant reference proteomes. We continue to manually curate the scientific literature to add the latest functional data and use machine learning techniques. We also encourage community curation to ensure key publications are not missed. We provide an update on the automatic annotation methods used by UniProtKB to predict information for unreviewed entries describing unstudied proteins. Finally, updates to the UniProt website are described, including a new tab linking protein to genomic information. In recognition of its value to the scientific community, the UniProt database has been awarded Global Core Biodata Resource status. [GRAPHICS] .

引用

页码：D609 / D617

页数：9

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