BREAKING THE BARRIERS WITH CUTTING-EDGE INTRADERMAL DELIVERY TOWARDS PAIN-FREE SKIN THERAPY: DISSOLVABLE MICRO NEEDLE DEVICES FOR LOCALIZED THERAPY

Quest for an efficient therapy with controlled and accurate delivery specifically at the ailment site leads o development of advanced localized delivery systems. In this league, microneedle devices are current trends of pain free localized intradermal delivery [1]. Moreover, microneedle devices have evolved as protagonist for skin through delivery aspects in various skin diseases including skin cancer [2-3]. Current treatment options for skin cancer have limitations of dose-limiting toxicity and side effects. Therefore, it is important to treat malignancies and affected lymph nodes with accuracy while sparing normal tissue [4]. The objective of research is to develop localized therapy for skin cancer using biodegradable microneedle devices. Reinvigorated from our previous findings on development of naringenin loaded sericin based microemulsion gel for photoaging [5], we explored programmed delivery strategies for localized skin delivery. To demonstrate the programmed localized delivery through microneedle device, we designed synthetic UV responsive polymer and coat that on biodegradable microneedles through layer-by-layer polyelectrolyte coating method. In this study, we focused on investigation of UV responsive release behavior of microneedles and extent of localized delivery of nanocarriers from microneedles for noninvasive topical chemotherapy of melanoma. Our study will pave the way for a selective and programmed delivery based localized therapy on skin cancer. Altogether, localized programmable delivery of therapeutics may provide accurate treatment in many nonresectable solid tumors and residual cancer cells after primary cytoreductive surgery.