Triazole-Derived Ruthenium(II) Complexes as Novel Candidates for Cancer Therapy

被引：0

作者：

Lenis-Rojas, Oscar A. ^{[1
]}

Roma-Rodrigues, Catarina ^{[2
]}

Carvalho, Beatriz ^{[2
]}

Andrade, Vasco ^{[2
]}

Friaes, Sofia ^{[1
]}

Cabezas-Sainz, Pablo ^{[3
]}

Fernandez, Jhonathan Angel Araujo ^{[3
,4
]}

Vila, Sabela Fernandez ^{[3
]}

Arana, alvaro J. ^{[3
]}

Sanchez, Laura ^{[3
]}

Baptista, Pedro V. ^{[2
]}

Gomes, Clara S. B. ^{[5
]}

Fernandes, Alexandra R. ^{[2
]}

Royo, Beatriz ^{[1
]}

机构：

[1] ITQB NOVA, Inst Tecnol Quim & Biol Antonio Xavier, Av Republ, P-2780157 Oeiras, Portugal

[2] NOVA Univ Lisbon, Inst Hlth & Bioecon, NOVA Sch Sci & Technol, Associate Lab i4HB, Campus Caparica, P-2829516 Caparica, Portugal

[3] Univ Santiago de Compostela, Fac Vet, Dept Zool Genet & Antrool Fips, Campus Lugo, Lugo 27002, Spain

[4] Univ Estadual Campinas, Sch Med Sci, Dept Med Genet & Genom Med, Lab Zebrafish,UNICAMP, Sao Paulo, Brazil

[5] Univ Nova Lisboa, Fac Ciencias & Tecnol, Dept Quim, LAQV REQUIMTE, P-2829516 Caparica, Portugal

来源：

CHEMPLUSCHEM | 2025年 / 90卷 / 05期

关键词：

ruthenium; triazolylidenes; anticancer; CAM assay; zebrafish xenograft; IN-VITRO; ANTICANCER AGENTS; CARBENE; ZEBRAFISH; CELLS; ARENE-RUTHENIUM(II); ORGANOMETALLICS; MODULATION; IR(III); BONDS;

D O I：

10.1002/cplu.202400775

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

The first examples of Ru(II) eta 6-arene (benzene and p-cymene) complexes containing a bidentate triazolylidene-triazolide ligand have been prepared and fully characterized. Their antiproliferative effect has been investigated against tumour cells A2780 (ovarian carcinoma), HCT116 (colorectal carcinoma), and HCT116dox (colorectal carcinoma resistant to doxorubicin), and in human dermal fibroblasts. The Ru complex bearing the p-cymene arene group exhibited a stronger antiproliferative effect across all tested cell lines, while the benzene-containing complex displayed higher selectivity toward tumor cells. Both complexes induced apoptosis, likely through ROS production (in the benzene complex), and inhibited tumorigenic processes, including cell migration and angiogenesis. In zebrafish models, they showed strong selectivity for cancer cells with minimal toxicity to healthy cells, effectively reducing the proliferation of HCT116 colorectal cancer cells. This study provides the first in vivo evidence of the anticancer potential of Ru triazolylidenes in zebrafish models.

引用

页数：9

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