Severe cases of local cytokine release syndrome (CRS); craniocervical edema soon after chimeric antigen T-cell (CAR-T) therapy

被引：0

作者：

Nakamura, Naokazu ^{[1
]}

Jo, Tomoyasu ^{[1
,2
]}

Arai, Yasuyuki ^{[1
,2
]}

Kitawaki, Toshio ^{[1
]}

Nishikori, Momoko ^{[1
,3
]}

Mizumoto, Chisaki ^{[1
]}

Kanda, Junya ^{[1
]}

Yamashita, Kouhei ^{[1
]}

Nagao, Miki ^{[2
]}

Takaori-Kondo, Akifumi ^{[1
]}

机构：

[1] Kyoto Univ, Dept Hematol, Kyoto, Japan

[2] Kyoto Univ, Dept Clin Lab Med, Kyoto, Japan

[3] Kyoto Univ, Grad Sch Med, Dept Human Hlth Sci, Kyoto, Japan

来源：

OXFORD MEDICAL CASE REPORTS | 2025年 / 2025卷 / 01期

关键词：

chimeric antigen receptor T cell therapy; cytokine release syndrome; case report;

D O I：

10.1093/omcr/omae164

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Craniocervical edema appears soon after chimeric antigen receptor T-cell (CAR-T) therapy in some cases. This phenomenon is often observed right after systemic cytokine release syndrome (CRS), and it is called local CRS (L-CRS). In severe cases, L-CRS causes airway obstruction and asphyxia, but it is not yet well known among hematologists. In this report, we present mild and severe cases of L-CRS. Tocilizumab might have limited efficacy against L-CRS, and early administration of corticosteroids can be important. We hope that this case report raises awareness of L-CRS as an acute-onset adverse event after CAR-T therapy.

引用

页数：3

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