The role of T cells in vascular aging, hypertension, and atherosclerosis

被引：3

作者：

Deconne, Theodore M. ^{[1
]}

Buckley, David J. ^{[2
]}

Trott, Daniel W. ^{[2
]}

Martens, Christopher R. ^{[3
]}

机构：

[1] Wake Forest Univ, Bowman Gray Sch Med, Dept Internal Med, Winston Salem, NC 27109 USA

[2] Univ Texas Arlington, Dept Kinesiol, Arlington, TX USA

[3] Univ Delaware, Dept Kinesiol & Appl Physiol, Newark, DE 19716 USA

来源：

AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY | 2024年 / 327卷 / 06期

关键词：

inflammation; oxidative stress; T cells; vascular dysfunction; BLOOD-PRESSURE REGULATION; II-INDUCED HYPERTENSION; ENDOTHELIAL DYSFUNCTION; ANGIOTENSIN-II; CHOLINE-ACETYLTRANSFERASE; RISK-FACTORS; LYMPHOCYTES; CD4(+); ACTIVATION; INHIBITION;

D O I：

10.1152/ajpheart.00570.2024

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Vascular dysfunction has emerged as a significant risk factor for the development of cardio- and cerebrovascular diseases (CVDs), which are currently the leading cause of morbidity and mortality worldwide. T lymphocytes (T cells) have been shown to be important modulators of vascular function in primary aging and CVDs, likely by producing inflammatory cytokines and reactive oxygen species that influence vasoprotective molecules. This review summarizes the role of T cells on vascular function in aging, hypertension, and atherosclerosis in animals and humans, and discusses potential T-cell targeted therapeutics to prevent, delay, or reverse vascular dysfunction.

引用

页码：H1345 / H1360

页数：16

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