The role of T cells in vascular aging, hypertension, and atherosclerosis

被引：3

作者：

Deconne, Theodore M. ^{[1
]}

Buckley, David J. ^{[2
]}

Trott, Daniel W. ^{[2
]}

Martens, Christopher R. ^{[3
]}

机构：

[1] Wake Forest Univ, Bowman Gray Sch Med, Dept Internal Med, Winston Salem, NC 27109 USA

[2] Univ Texas Arlington, Dept Kinesiol, Arlington, TX USA

[3] Univ Delaware, Dept Kinesiol & Appl Physiol, Newark, DE 19716 USA

来源：

AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY | 2024年 / 327卷 / 06期

关键词：

inflammation; oxidative stress; T cells; vascular dysfunction; BLOOD-PRESSURE REGULATION; II-INDUCED HYPERTENSION; ENDOTHELIAL DYSFUNCTION; ANGIOTENSIN-II; CHOLINE-ACETYLTRANSFERASE; RISK-FACTORS; LYMPHOCYTES; CD4(+); ACTIVATION; INHIBITION;

D O I：

10.1152/ajpheart.00570.2024

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Vascular dysfunction has emerged as a significant risk factor for the development of cardio- and cerebrovascular diseases (CVDs), which are currently the leading cause of morbidity and mortality worldwide. T lymphocytes (T cells) have been shown to be important modulators of vascular function in primary aging and CVDs, likely by producing inflammatory cytokines and reactive oxygen species that influence vasoprotective molecules. This review summarizes the role of T cells on vascular function in aging, hypertension, and atherosclerosis in animals and humans, and discusses potential T-cell targeted therapeutics to prevent, delay, or reverse vascular dysfunction.

引用

页码：H1345 / H1360

页数：16

共 181 条

[1] Are senescence and exhaustion intertwined or unrelated processes that compromise immunity? [J].

Akbar, Arne N. ;

Henson, Sian M. .

NATURE REVIEWS IMMUNOLOGY, 2011, 11 (04) :289-295

[2] Immune Profiling Reveals Decreases in Circulating Regulatory and Exhausted T Cells in Human Hypertension [J].

Alexander, Matthew R. ;

Dale, Bethany L. ;

Smart, Charles D. ;

Elijovich, Fernando ;

Wogsland, Cara E. ;

Lima, Sierra M. ;

Irish, Jonathan M. ;

Madhur, Meena S. .

JACC-BASIC TO TRANSLATIONAL SCIENCE, 2023, 8 (03) :319-336

[3] Anti-IL-17 monoclonal antibodies in hospitalized patients with severe COVID-19: A pilot study [J].

Avdeev, Sergey N. ;

V. Trushenko, Natalia ;

Tsareva, Natalia A. ;

Yaroshetskiy, Andrey I. ;

Merzhoeva, Zamira M. ;

Nuralieva, Galia S. ;

V. Nekludova, Galina ;

Chikina, Svetlana Yu. ;

Gneusheva, Tatiana Yu. ;

Suvorova, Olga A. ;

Shmidt, Anna E. .

CYTOKINE, 2021, 146

[4] Immunosenescence: emerging challenges for an ageing population [J].

Aw, Danielle ;

Silva, Alberto B. ;

Palmer, Donald B. .

IMMUNOLOGY, 2007, 120 (04) :435-446

[5] Mitochondrial Respiration Controls Lysosomal Function during Inflammatory T Cell Responses [J].

Baixauli, Francesc ;

Acin-Perez, Rebeca ;

Villarroya-Beltri, Carolina ;

Mazzeo, Carla ;

Nunez-Andrade, Norman ;

Gabande-Rodriguez, Enrique ;

Dolores Ledesma, Maria ;

Blazquez, Alberto ;

Angel Martin, Miguel ;

Manuel Falcon-Perez, Juan ;

Miguel Redondo, Juan ;

Antonio Enriquez, Jose ;

Mittelbrunn, Maria .

CELL METABOLISM, 2015, 22 (03) :485-498

[6] T Regulatory Lymphocytes Prevent Angiotensin II-Induced Hypertension and Vascular Injury [J].

Barhoumi, Tlili ;

Kasal, Daniel A. ;

Li, Melissa W. ;

Shbat, Layla ;

Laurant, Pascal ;

Neves, Mario F. ;

Paradis, Pierre ;

Schiffrin, Ernesto L. .

HYPERTENSION, 2011, 57 (03) :469-U245

[7] High-Dimensional Single-Cell Multimodal Landscape of Human Carotid Atherosclerosis [J].

Bashore, Alexander C. ;

Yan, Hanying ;

Xue, Chenyi ;

Zhu, Lucie Y. ;

Kim, Eunyoung ;

Mawson, Thomas ;

Coronel, Johana ;

Chung, Allen ;

Sachs, Nadja ;

Ho, Sebastian ;

Ross, Leila S. ;

Kissner, Michael ;

Passegue, Emmanuelle ;

Bauer, Robert C. ;

Maegdefessel, Lars ;

Li, Mingyao ;

Reilly, Muredach P. .

ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY, 2024, 44 (04) :930-945

[8] T cell cholesterol efflux suppresses apoptosis and senescence and increases atherosclerosis in middle aged mice [J].

Bazioti, Venetia ;

La Rose, Anouk M. ;

Maassen, Sjors ;

Bianchi, Frans ;

de Boer, Rinse ;

Halmos, Benedek ;

Dabral, Deepti ;

Guilbaud, Emma ;

Flohr-Svendsen, Arthur ;

Groenen, Anouk G. ;

Marmolejo-Garza, Alejandro ;

Koster, Mirjam H. ;

Kloosterhuis, Niels J. ;

Havinga, Rick ;

Pranger, Alle T. ;

Langelaar-Makkinje, Miriam ;

de Bruin, Alain ;

van de Sluis, Bart ;

Kohan, Alison B. ;

Yvan-Charvet, Laurent ;

van den Bogaart, Geert ;

Westerterp, Marit .

NATURE COMMUNICATIONS, 2022, 13 (01)

[9] Greater T Regulatory Cells in Females Attenuate DOCA-Salt-Induced Increases in Blood Pressure Versus Males [J].

Belanger, Kasey M. ;

Crislip, G. Ryan ;

Gillis, Ellen E. ;

Abdelbary, Mahmoud ;

Musall, Jacqueline B. ;

Mohamed, Riyaz ;

Baban, Babak ;

Elmarakby, Ahmed ;

Brands, Michael W. ;

Sullivan, Jennifer C. .

HYPERTENSION, 2020, 75 (06) :1615-1623

[10] Mitochondrial dysfunction and oxidative stress in metabolic disorders - A step towards mitochondria based therapeutic strategies [J].

Bhatti, Jasvinder Singh ;

Bhatti, Gurjit Kaur ;

Reddy, P. Hemachandra .

BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE, 2017, 1863 (05) :1066-1077

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