Fluorine-Based Oxidant Enables Room-Temperature Pd-Catalyzed C-H Arylation with Boronic Acids

被引：0

作者：

Pichon-Barre, Delphine S. ^{[1
]}

McDonald, Nicholas R. ^{[1
]}

Romero, Erik A. ^{[1
]}

机构：

[1] Univ Calif San Diego, Dept Chem & Biochem, La Jolla, CA 92093 USA

来源：

JOURNAL OF ORGANIC CHEMISTRY | 2025年

关键词：

ACTIVATION; MECHANISM; BONDS; ALKENYLATION; SELECTFLUOR; C(SP(2))-H; COUPLINGS; ARENES;

D O I：

10.1021/acs.joc.4c03106

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The biaryl motif is important in many fields within chemistry and the life sciences. Thus, better strategies to forge aryl-aryl bonds are valuable. Herein, we report conditions permitting the room temperature arylation of N-aryl amide substrates, using ubiquitous aryl boronic acid reagents. Critical to the success of this method is the use of Selectfluor as a sustainable alternative oxidant to silver-based additives and the deployment of a bulky QuinOx ligand supporting the palladium catalyst.

引用

页数：5

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