Design and Synthesis of Unsymmetric Benzils, Quinoxalines, and Evaluations of their Anticancer Activities against Human Non-Small Lung Cancer Cells

被引：0
作者：
Hsu, Ping-Chih [1 ,2 ]
Hsu, Yu-Hsin [3 ]
Chang, Chuan-Hsin [4 ,5 ]
Shih, Tzenge-Lien [3 ]
机构：
[1] Chang Gung Mem Hosp Linkou, Dept Internal Med, Div Thorac Med, Taoyuan 333423, Taiwan
[2] Chang Gung Univ, Coll Med, Dept Med, Taoyuan 333323, Taiwan
[3] Tamkang Univ, Dept Chem, New Taipei City 251301, Taiwan
[4] Chang Gung Univ Sci & Technol, Grad Inst Hlth Ind Technol, Coll Human Ecol, Res Ctr Chinese Herbal Med, Taoyuan 333324, Taiwan
[5] Taipei Tzu Chi Hosp, Buddhist Tzu Chi Med Fdn, Dept Res, New Taipei City 231405, Taiwan
来源：
CHEMMEDCHEM | 2025年 / 20卷 / 06期
关键词：
Anticancer activities; Unsymmetric benzil; Unsymmetric quinoxaline; Sonogarshira reaction; OXIDATION; DERIVATIVES; INHIBITION; DIPHENYLETHANE-1,2-DIONE; APOPTOSIS; ANALOGS;
D O I：
10.1002/cmdc.202400847
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
Quinoxaline and its derivatives exhibit a broad spectrum of biological activity, making them valuable for various therapeutic applications. However, most quinoxalines are synthetically produced due to their scarcity in nature. In this article, a series of unsymmetric benzils were synthesized and subsequently condensed with 1,2-diaminobenzene to produce unsymmetric quinoxalines. The novel synthetic benzils and quinoxalines were evaluated for their anticancer activities against human non-small-cell lung cancer (NSCLC) cells harboring different gene mutations, to explore their potential as anticancer agents. Among these synthesized molecules, compound 5 g demonstrated inhibitory effects comparable to those of cisplatin.
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页数：10
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