Red blood cell derived nanocarrier drug delivery system: A promising strategy for tumor therapy

被引：7
作者：
Wang, Xin [1 ,2 ,3 ]
Mao, Kuirong [1 ,2 ,4 ]
Zhang, Xiaonan [5 ]
Zhang, Yuning [1 ,2 ,4 ]
Yang, Yong-Guang [1 ,2 ,4 ]
Sun, Tianmeng [1 ,2 ,4 ,6 ]
机构：
[1] First Hosp Jilin Univ, Inst Immunol, Key Lab Organ Regenerat & Transplantat, Minist Educ, Changchun, Jilin, Peoples R China
[2] Natl Local Joint Engn Lab Anim Models Human Dis, Changchun, Jilin, Peoples R China
[3] Inner Mongolia Minzu Univ, Med Lab Ctr, Affiliated Hosp, Tongliao, Inner Mongolia, Peoples R China
[4] Jilin Univ, Int Ctr Future Sci, Changchun, Jilin, Peoples R China
[5] Uppsala Univ, Dept Immunol Genet & Pathol, Uppsala, Sweden
[6] Jilin Univ, State Key Lab Supramol Struct & Mat, Changchun, Jilin, Peoples R China
来源：
INTERDISCIPLINARY MEDICINE | 2024年 / 2卷 / 03期
基金：
中国国家自然科学基金;
关键词：
erythrocyte membrane coating; nanoparticles drug delivery system; RBC-hitchhiking; RBCs; tumor therapy; IN-VITRO; NANOPARTICLES; MEMBRANE; NANOSUSPENSIONS; ERYTHROCYTES; HITCHHIKING; BIODISTRIBUTION; NANOMEDICINE; NANODIAMONDS; CHALLENGES;
D O I：
10.1002/INMD.20240014
中图分类号：
R-3 [医学研究方法]; R3 [基础医学];
学科分类号：
1001 ;
摘要：
Nano drug delivery systems have been widely used in tumor therapy. Researchers have been devoted to exploring novel nano-carriers to prolong circulation time biocompatibility and tumor targeting efficiency in vivo. Erythrocyte membranes as bionic nano-drug delivery systems have attracted more attention recently. There are abundant red blood cells (RBCs) in circulation, which are natural carriers for nanomaterial delivery. There are mainly two strategies to use RBCs as nanomaterial carriers: RBC-hitchhiking and bionic nanomaterial coated with erythrocyte membrane loading with drugs. Although nano-carrier based on RBCs have yielded some progress, the mechanism of mutual effect between nanoparticles and RBCs is still unclear. Here, we review the effects of nanoparticles on RBCs (morphology and function, etc) and application of RBCs membrane as nano-drug delivery carriers in tumor therapy. RBC derived nanocarrier drug delivery systems were applied in tumor treatment by two types: (A) RBC-hitchhiking and (B) RBC membrane coating. image
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页数：16
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