The roles of pyroptosis in the pathogenesis of autoimmune diseases

被引：0

作者：

Song, Yingqiu ^{[1
,2
]}

Peng, Yanhui ^{[1
,2
]}

Wang, Bing ^{[1
,2
]}

Zhou, Xinyue ^{[1
,2
]}

Cai, Yikang ^{[1
,2
]}

Chen, Haiyong ^{[3
]}

Miao, Chenggui ^{[1
,2
,3
,4
]}

机构：

[1] Anhui Univ Chinese Med, Ctr Xinan Med & Modernizat Tradit Chinese Med IHM, Hefei, Anhui, Peoples R China

[2] Anhui Univ Chinese Med, Sch Integrated Chinese & Western Med, Dept Pharmacol, 350 Longzihu Rd, Hefei 230012, Anhui, Peoples R China

[3] Univ Hong Kong, Li Ka Shing Fac Med, Sch Chinese Med, Hong Kong, Peoples R China

[4] Anhui Univ Chinese Med, Inst Prevent & Treatment Rheumatoid Arthrit, Hefei, Anhui, Peoples R China

来源：

LIFE SCIENCES | 2024年 / 359卷

基金：

中国国家自然科学基金;

关键词：

Pyroptosis; Autoimmune diseases; Mechanism; Inflammasome; Immune; GASDERMIN D; NLRP3; INFLAMMASOME; CELL-DEATH; ENCEPHALOMYELITIS; METABOLISM; ACTIVATION; EXPRESSION; MECHANISM;

D O I：

10.1016/j.lfs.2024.123232

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

The occurrence of autoimmune diseases is a result of the immune system's immune response against healthy components of the body. Pyroptosis is an innovative form of programmed cell death dependent on inflammatory caspases, leading to the release of cytokines. Excessive pyroptosis can lead to a sustained inflammatory response, which may aggravate the development of autoimmune diseases. In rheumatoid arthritis (RA), tumor necrosis factor (TNF) and NLRP3 enhance pyroptosis, exacerbating the disease. In systemic lupus erythematosus (SLE), the release of nuclear antigen promotes the development of SLE. In multiple sclerosis (MS), elevated active caspase-11 in primary astrocytes induces oligodendrocyte pyroptosis, advancing MS progression. This review outlines the mechanisms of pyroptosis in autoimmune diseases. Meanwhile, we elaborated the possible therapeutic targets from the perspective of pyroptosis. We conclude that pyroptosis is expected to be a therapeutic target for autoimmune diseases.

引用

页数：10

共 96 条

[61] K+ Efflux Is the Common Trigger of NLRP3 Inflammasome Activation by Bacterial Toxins and Particulate Matter [J].

Munoz-Planillo, Raul ;

Kuffa, Peter ;

Martinez-Colon, Giovanny ;

Smith, Brenna L. ;

Rajendiran, Thekkelnaycke M. ;

Nunez, Gabriel .

IMMUNITY, 2013, 38 (06) :1142-1153

[62] NLRC4 expression in intestinal epithelial cells mediates protection against an enteric pathogen [J].

Nordlander, S. ;

Pott, J. ;

Maloy, K. J. .

MUCOSAL IMMUNOLOGY, 2014, 7 (04) :775-785

[63] The Effects of IFN-β 1a on the Expression of Inflammasomes and Apoptosis-Associated Speck-Like Proteins in Multiple Sclerosis Patients [J].

Noroozi, Saam ;

Meimand, Hossein Ali Ebrahimi ;

Arababadi, Mohammad Kazemi ;

Nakhaee, Nouzar ;

Asadikaram, Gholamreza .

MOLECULAR NEUROBIOLOGY, 2017, 54 (04) :3031-3037

[64] Restoring synovial homeostasis in rheumatoid arthritis by targeting fibroblast-like synoviocytes [J].

Nygaard, Gyrid ;

Firestein, Gary S. .

NATURE REVIEWS RHEUMATOLOGY, 2020, 16 (06) :316-333

[65] Pyroptosis in inflammatory diseases and cancer [J].

Rao, Zhiping ;

Zhu, Yutong ;

Yang, Peng ;

Chen, Zhuang ;

Xia, Yuqiong ;

Qiao, Chaoqiang ;

Liu, Weijing ;

Deng, Hongzhang ;

Li, Jianxiong ;

Ning, Pengbo ;

Wang, Zhongliang .

THERANOSTICS, 2022, 12 (09) :4310-4329

[66] Chemical disruption of the pyroptotic pore-forming protein gasdermin D inhibits inflammatory cell death and sepsis [J].

Rathkey, Joseph K. ;

Zhao, Junjie ;

Liu, Zhonghua ;

Chen, Yinghua ;

Yang, Jie ;

Kondolf, Hannah C. ;

Benson, Bryan L. ;

Chirieleison, Steven M. ;

Huang, Alex Y. ;

Dubyak, George R. ;

Xiao, Tsan S. ;

Li, Xiaoxia ;

Abbott, Derek W. .

SCIENCE IMMUNOLOGY, 2018, 3 (26)

[67] IL-37 alleviates TNF-α-induced pyroptosis of rheumatoid arthritis fibroblast-like synoviocytes by inhibiting the NF-κB/GSDMD signaling pathway [J].

Ren, Chunfeng ;

Chen, Jie ;

Che, Qincheng ;

Jia, Qian ;

Lu, Hongqin ;

Qi, Xiaoyan ;

Zhang, Xiaojie ;

Shu, Qiang .

IMMUNOBIOLOGY, 2023, 228 (03)

[68] Damage-Associated Molecular Patterns in Inflammatory Diseases [J].

Roh, Jong Seong ;

Sohn, Dong Hyun .

IMMUNE NETWORK, 2018, 18 (04)

[69] Cisplatin in cancer treatment [J].

Romani, Andrea M. P. .

BIOCHEMICAL PHARMACOLOGY, 2022, 206

[70] Autophagy: A critical regulator of cellular metabolism and homeostasis [J].

Ryter, Stefan W. ;

Cloonan, Suzanne M. ;

Choi, Augustine M. K. .

MOLECULES AND CELLS, 2013, 36 (01) :7-16

← 1 2 3 4 5 6 7 8 9 10 →