Stereocontrolled synthesis of an α-monosubstituted α-amino acid derivative from a Ugi reaction product

被引：0
|
作者：
Tsukamoto, Shuntaro [1 ]
Suzuki, Yuki [1 ]
Oikawa, Masato [1 ]
机构：
[1] Yokohama City Univ, Seto 22?2 Kanazawa Ku, Yokohama 2360027, Japan
来源：
TETRAHEDRON LETTERS | 2025年 / 157卷
关键词：
alpha-amino acid; Ugi reaction; Chiral morpholinone; ASYMMETRIC-SYNTHESIS; STEREOSELECTIVE-SYNTHESIS; ASSIGNMENT;
D O I：
10.1016/j.tetlet.2025.155488
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
We report herein an unprecedented concept for an enantiospecific synthetic strategy for alpha-amino acid derivatives starting from Ugi four-component coupling reaction employing chiral amine, via a chiral morpholinone intermediate. This concept was proven by the successful synthesis of (S)-N-Ac-tert-leucine.
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页数：4
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