Association between psychiatric disorders and the risk of stroke: a meta-analysis of cohort studies

被引：0
作者：
Hu, Zhonghou [1 ]
Sun, Weishan [1 ]
Cui, Enxiu [1 ]
Chen, Bo [1 ]
Zhang, Mi [1 ]
机构：
[1] Yancheng Fourth Peoples Hosp, Dept Psychiat 3, Yancheng, Peoples R China
来源：
FRONTIERS IN NEUROLOGY | 2024年 / 15卷
关键词：
psychiatric disorders; stroke; meta-analysis; cohort studies; risk; CORONARY-HEART-DISEASE; DEPRESSIVE SYMPTOMS; ISCHEMIC-STROKE; BIPOLAR DISORDER; MENTAL-DISORDERS; OLDER-ADULTS; MORTALITY; SCHIZOPHRENIA; PREVALENCE; COMMUNITY;
D O I：
10.3389/fneur.2024.1444862
中图分类号：
R74 [神经病学与精神病学];
学科分类号：
摘要：
Background: Psychiatric disorders may be associated with an elevated risk of stroke; however, the existence of variations in this association between different populations remains controversial. Consequently, we conducted a comprehensive systematic review and meta-analysis to examine the magnitude of the relationship between psychiatric disorders and the risk of stroke. Methods: The PubMed, Embase, and Cochrane Library databases were systematically searched to identify eligible studies from inception to April 2024. The aggregated findings were expressed as relative risks (RRs) with 95% confidence intervals (CIs), and the combined analysis was performed using a random-effects modeling approach. Further exploratory analyses were also performed using sensitivity and subgroup analyses. Results: A total of 36 cohort studies, involving 25,519,635 individuals, were selected for analysis. We noted that depression (RR: 1.50; 95% CI: 1.34-1.68; p < 0.001), schizophrenia (RR: 1.74; 95% CI: 1.36-2.24; p < 0.001), and bipolar disorder (RR: 1.65; 95% CI: 1.27-2.14; p < 0.001) were associated with an elevated risk of stroke. Further exploratory analyses found that the association between depression and the risk of stroke differed according to the adjusted level (RR ratio: 0.77; 95% CI: 0.61-0.98; p = 0.034), and the association between schizophrenia and the risk of stroke differed according to the outcome definition (RR ratio: 0.68; 95% CI: 0.52-0.90; p = 0.006). Moreover, the association between bipolar disorder and the risk of stroke differed according to the study design (RR ratio: 0.68; 95% CI: 0.55-0.84; p < 0.001). Conclusion: The significant association between psychiatric disorders and an elevated risk of stroke highlights the importance of enhanced monitoring and stroke prevention in patients with psychiatric disorders. Systematic review registration Our study was registered on the INPLASY platform (number: INPLASY202450049).
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页数：15
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