Glut-1-Negative Choroidal Malignant Melanoma with Liver Metastasis Recurrence 12 Years after Surgery without FDG Accumulation in a Recurrent Lesion on FDG-PET/CT: a Case Report

被引：0

作者：

Shimamoto, Toyoki ^{[1
]}

Ochi, Hironori ^{[1
]}

Fang, Cao ^{[1
]}

Amano, Michiko ^{[1
]}

Tanaka, Takaaki ^{[1
]}

Azemoto, Nobuaki ^{[1
]}

Mashiba, Toshie ^{[1
]}

Kimura, Koichi ^{[2
]}

Minagawa, Ryosuke ^{[2
]}

Ooshiro, Yumi ^{[3
]}

Kodama, Toshio ^{[4
]}

Yokota, Tomoyuki ^{[1
]}

机构：

[1] Matsuyama Red Cross Hosp, Dept Liver Biliary Pancreat Dis, Matsuyama, Japan

[2] Matsuyama Red Cross Hosp, Dept Surg, Matsuyama, Japan

[3] Matsuyama Red Cross Hosp, Dept Pathol, Matsuyama, Japan

[4] Matsuyama Red Cross Hosp, Dept Ophthalmol, Matsuyama, Japan

来源：

INTERNAL MEDICINE | 2025年 / 64卷 / 09期

关键词：

choroidal malignant melanoma; metastatic liver tumor; PET/CT; UVEAL MELANOMA; METAANALYSIS; PROGNOSIS;

D O I：

10.2169/internalmedicine.4204-24

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Choroidal malignant melanoma is a rare malignant tumor that develops in adult eyeballs. It causes early lymph node and distant metastasis. Fluorodeoxyglucose (FDG)-positron emission tomography/computed tomography (CT) is widely used for screening malignant melanoma metastases. We encountered a 58-year-old man with choroidal malignant melanoma in whom liver metastasis recurred 12 years after surgery, without any observable FDG accumulation. Immunostaining revealed the absence of glucose transporter type 1 (GLUT-1) expression, crucial for intracellular FDG uptake. The lack of FDG accumulation in the lesion could be attributed to the diminished cellular FDG uptake due to the absence of GLUT-1 expression.

引用

页码：1327 / 1333

页数：7

共 25 条

[1]

Avril N, 2004, J NUCL MED, V45, P930

[2] The Application of Artificial Intelligence in the Analysis of Biomarkers for Diagnosis and Management of Uveitis and Uveal Melanoma: A Systematic Review [J].

Bassi, Arshpreet ;

Krance, Saffire H. ;

Pucchio, Aidan ;

Pur, Daiana R. ;

Miranda, Rafael N. ;

Felfeli, Tina .

CLINICAL OPHTHALMOLOGY, 2022, 16 :2895-2908

[3] LATE RECURRENCE OF MALIGNANT-MELANOMA - ANALYSIS OF 168 PATIENTS [J].

CROWLEY, NJ ;

SEIGLER, HF .

ANNALS OF SURGERY, 1990, 212 (02) :173-177

[4] Differences in glucose metabolic activity in liver metastasis separates two groups of metastatic uveal melanoma patients with different prognosis [J].

del Carpio, Luis P. ;

Algarra, Maria Asuncion ;

Sabate-Llobera, Aida ;

Rodriguez-Vida, Alejo ;

Rossi-Seoane, Susana ;

Ruiz, Sandra ;

Leiva, David ;

Ramos, Emilio ;

Llado, Laura ;

Lorenzo, Daniel ;

Gutierrez, Cristina ;

Cortes-Romera, Montserrat ;

Caminal, Josep M. ;

Piulats, Josep M. .

CANCER MEDICINE, 2023, 12 (13) :14062-14071

[5] Expression of Glut-1 in Malignant Melanoma and Melanocytic Nevi: an Immunohistochemical Study of 400 Cases [J].

Dura, Miroslav ;

Nemejcova, Kristyna ;

Jaksa, Radek ;

Bartu, Michaela ;

Kodet, Ondrej ;

Ticha, Ivana ;

Michalkova, Romana ;

Dundr, Pavel .

PATHOLOGY & ONCOLOGY RESEARCH, 2019, 25 (01) :361-368

[6] Clinical and histopathological characteristics and survival analysis of 4594 Japanese patients with melanoma [J].

Fujisawa, Yasuhiro ;

Yoshikawa, Shusuke ;

Minagawa, Akane ;

Takenouchi, Tatsuya ;

Yokota, Kenji ;

Uchi, Hiroshi ;

Noma, Naoki ;

Nakamura, Yasuhiro ;

Asai, Jun ;

Kato, Jiinji ;

Fujiwara, Susumu ;

Fukushima, Satoshi ;

Uehara, Jiro ;

Hoashi, Toshihiko ;

Kaji, Tatsuya ;

Fujimura, Taku ;

Namikawa, Kenjiro ;

Yoshioka, Manabu ;

Murao, Naoki ;

Ogata, Dai ;

Matsuyama, Kanako ;

Hatta, Naohito ;

Shibayama, Yoshitsugu ;

Fujiyama, Toshiharu ;

Ishikawa, Masashi ;

Yamada, Daisuke ;

Kishi, Akiko ;

Nakamura, Yoshiyuki ;

Shimiauchi, Takatoshi ;

Fujii, Kazuyasu ;

Fujimoto, Manabu ;

Ihn, Hironobu ;

Katoh, Norito .

CANCER MEDICINE, 2019, 8 (05) :2146-2156

[7]

Fukuda T, 1994, GASTROINTEST ENDOSC, V36, P1597

[8]

Hosonuma Kenichi, 2005, Nihon Shokakibyo Gakkai Zasshi, V102, P1201

[9]

KATH R, 1993, CANCER, V72, P2219, DOI 10.1002/1097-0142(19931001)72:7<2219::AID-CNCR2820720725>3.0.CO

[10]

2-J

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