Malnutrition defined by Controlling Nutritional Status score was independently associated with prognosis of diffuse large B-cell lymphoma primarily on elderly patients

被引:0
作者
Wang, Fei [1 ]
Lu, Luo [1 ]
Zang, Haoyu [1 ]
Yue, Yanhua [1 ]
Cao, Yang [1 ]
Chen, Min [1 ]
Liu, Yue [1 ]
Gu, Weiying [1 ]
He, Bai [1 ]
机构
[1] Soochow Univ, Peoples Hosp Changzhou 1, Affiliated Hosp 3, Dept Hematol, Changzhou, Peoples R China
关键词
Diffuse Large B-cell Lymphoma; prognosis; malnutrition; Controlling Nutritional Status score; elderly patients; STATUS CONUT SCORE; CANCER; CACHEXIA;
D O I
10.1080/16078454.2024.2434276
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Objectives: Controlling Nutritional Status (CONUT) Score is an effective tool for the assessment of malnutrition and proved to be associated with survival of Diffuse large B-cell lymphoma (DLBCL) patients. We investigated the impact of CONUT score on specific subgroups of DLBCL patients, including age and International prognostic Index (IPI) risk groups. Methods: Data of 287 newly diagnosed DLBCL in the Third Affiliated Hospital of Soochow University were retrospectively collected. Baseline CONUT score, clinical data and survival information were recorded. Results: With the standard cut-off value of 4 points, 88 (30.7%) patients were clarified as malnourished. During a median follow-up of 34 months, malnourished patients exhibited significant reduction in both progression-free survival (PFS) and overall survival (OS). The 3-year PFS rates for malnourished and well-nourished patients were 51.4% and 70.9% (p = 0.001), while the 3-year OS rates were 62.4% and 84.0% (p < 0.001). Malnutrition was demonstrated an independent predictor of OS in DLBCL patients (HR 2.220, 95% CI 1.307-3.772, p = 0.003). It could effectively identify patients with inferior OS in both low/intermediate-low risk and intermediate-high/high risk IPI groups. In the group of elderly patients aged over 60 years, malnutrition was independently associated with OS (HR 2.182, 95% CI 1.178-4.040, p = 0.024), but not PFS (HR 1.709, 95% CI 1.016-2.875, p = 0.070) after adjustment using the Benjamini-Hochberg procedure. Conversely, for younger patients, malnutrition did not demonstrate an independent impact on either PFS or OS. Conclusion: Malnutrition evaluated by CONUT score was an independent predictor for the outcome of DLBCL patients, which is exclusively caused by its effect on elderly patients.
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页数:10
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