Mucosal targeting in IgA nephropathy targeting the gut associated lymphoid tissue

被引：0

作者：

Barratt, Jonathan ^{[1
,2
]}

机构：

[1] Univ Leicester, Leicester, England

[2] John Walls Renal Unit, Leicester, England

来源：

NEPHROLOGY | 2024年 / 29卷

关键词：

glomerulonephritis (GN); IgA nephropathy; immunology; O-GLYCOSYLATION; SECRETORY IGA; COSMC;

D O I：

10.1111/nep.14365

中图分类号：

R5 [内科学]; R69 [泌尿科学（泌尿生殖系疾病）];

学科分类号：

1002 ; 100201 ;

摘要：

IgA nephropathy is a mucosally driven disease and new therapeutic approaches are specifically targeting the mucosal production of IgA in the hope that this will lead to a reduction in circulating IgA immune complexes and mesangial IgA deposition. In this lecture, I discuss the rationale for targeting the mucosal immune system of the gut and the existing data from clinical trials supporting such an approach as a disease modifying treatment for IgA nephropathy.

引用

页码：34 / 36

页数：3

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