The first type of binuclear copper complex with terminal sulfide: synthesis, structural characterization, and cytotoxicity evaluation

被引：0

作者：

Hussein, Mouayed A. ^{[1
]}

Al-Yaseen, Alaa A. ^{[1
]}

机构：

[1] Univ Basrah, Coll Sci, Dept Chem, Basrah 61001, Iraq

来源：

JOURNAL OF SULFUR CHEMISTRY | 2025年 / 46卷 / 02期

关键词：

P-aminobenzene sulfonamide; crystal structure; copper complex; esophageal cancer; SKGT-4 cell lines; N2O;

D O I：

10.1080/17415993.2024.2416237

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A novel copper complex of [CuII (mu 2-S)(terminal-S)(2-acetylpyrdine oxime)2 (1) is synthesized and characterized by X-ray single-crystal diffraction. The free ligand of 2-acetylpyrdine oxime is an unexpected product obtained from a condensation reaction of p-aminobenzene sulfonamide and 2-acetylpyridine and is characterized by IR, 1HNMR, and 13CNMR spectroscopic methods. X-ray crystallography showed strictly planar bridged mu 2- Cu2(S)2 core, and each copper(II) center exhibits distorted square pyramidal coordination geometry. The cytotoxicity of the complex was tested in vitro against esophageal cancer (SKGT-4) cell lines by metabolic tests, using 3-(4, 5-dimethylthiazol-2-yl)-2,5-diphenyl-tetrazolium bromide as a reagent. Complex 1 showed a remarkable inhibition response in SKGT-4 cell lines.

引用

页码：345 / 357

页数：13

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