Effects of White Noise Intervention on Sleep Quality and Immunological Indicators of Patients with Breast Cancer Undergoing Neoadjuvant Chemotherapy

被引：0

作者：

Yin, Gang ^{[1
]}

Li, Na ^{[2
]}

Xu, Dan ^{[3
]}

Meng, Zhen ^{[4
]}

Zheng, Shuyun ^{[5
]}

Chen, Ying ^{[6
]}

机构：

[1] Univ Hlth & Rehabil Sci, Qingdao Cent Hosp, Qingdao Cent Hosp, Qingdao 266000, Peoples R China

[2] Univ Hlth & Rehabil Sci, Qingdao Cent Hosp, Intens Care Med Dept, Qingdao 266000, Peoples R China

[3] Univ Hlth & Rehabil Sci, Qingdao Cent Hosp, PICC Clin, Qingdao 266000, Peoples R China

[4] Zhangqiu Dist Peoples Hosp, Dept Ultrasound, Jinan 250200, Peoples R China

[5] Jinan Zhangqiu Dist Peoples Hosp, Dept Pediat, Jinan 250200, Peoples R China

[6] Qingdao Municipal Hosp, Dept Geriatr Hlth Internal Med, Qingdao 266000, Peoples R China

来源：

NOISE & HEALTH | 2024年 / 26卷 / 123期

关键词：

Breast cancer; Noise; Chemotherapy; Sleep quality; Immunological; MANAGEMENT; WOMEN;

D O I：

10.4103/nah.nah_111_24

中图分类号：

R36 [病理学]; R76 [耳鼻咽喉科学];

学科分类号：

100104 ; 100213 ;

摘要：

Objective: Evaluate the effect of white noise intervention on sleep quality and immunological indicators of patients with breast cancer undergoing neoadjuvant chemotherapy (NAC). Methods: From January 2020 to December 2022, 104 newly diagnosed female patients (the number of people who met the inclusion criteria) with breast cancer who were confirmed to be preoperative NAC by puncture pathology were selected for a randomised single-blind trial. The patients were randomly divided into an observation group and a control group, with 52 cases in each group. The control group of patients received routine NAC treatment. The observation group played white noise at regular intervals every night on the basis of routine NAC, covering the entire treatment cycle. We evaluated the clinical efficacy, safety, sleep quality and immunological indicators of the two groups. Results: We found no statistically significant difference in the objective response rate between the two groups (P > 0.05). There was no statistically significant difference in the incidence of safety events between the two groups (P > 0.05). The total incidence of adverse reactions in the observation group was significantly lower than that in the control group (P < 0.05). After intervention, the sleep latency, subjective sleep quality, sleep duration, daytime function and sleep disorder scores of both groups decreased, and the observation group had significantly lower scores than the control group (P < 0.05). After intervention, both groups showed changes in immunoglobulin A (IgA), immunoglobulin G (IgG), immunoglobulin M (IgM), C-reactive protein and serum interleukin-6, but the differences between the groups were not statistically significant (P > 0.05). Conclusion: White noise intervention can improve the sleep quality of the NAC population with breast cancer and reduce the incidence of adverse reactions. In addition, it has no effect on the treatment efficacy, safety and immune indicators of patients.

引用

页码：577 / 583

页数：7

共 20 条

[1]

Li F, Zhao X, Han Z, Et al., Coherence sidelobe suppression of laser diode by white-noise-current modulation and external cavity feedback, Opt Lett, 49, pp. 4218-4221, (2024)

[2]

Ma AC, Rosi-Schumacher M, Corbin AF, Et al., White noise use among children undergoing sound field audiometry: a preliminary study, Int J Pediatr Otorhinolaryngol, 181, (2024)

[3]

Gokturk G, Sarialioglu A., Effect of white noise during nasal continuous positive airway pressure application on newborn’s pain and stress levels, physiological parameters, and crying durations: a randomized controlled study, J Pediatr Nurs, S0882-5963, 24, pp. 00284-00287, (2024)

[4]

Kadiroglu T, Yalcin R, Guven M., Effect of Yakson touch and white noise on pain in neonatal heel blood collection: a randomized controlled study, Altern Ther Health Med, 2024

[5]

Yin P, Fan Q, Liu L, Et al., Efficacy of acupuncture treatment for breast cancer-related insomnia: study protocol for a multicenter randomized controlled trial, Front Psychiatry, 15, (2024)

[6]

Tolstrup LK, Dieperink KB, Van Leeuwen M, Et al., Health-related quality of life in Danish cancer survivors referred to a late effects clinic: a prospective cohort study, Acta Oncol, 63, pp. 426-432, (2024)

[7]

Hao Q, Dai L, Chang L, Et al., Evaluation of neoadjuvant chemotherapy for clinical T1 triple-negative breast cancer, Sci Rep, 14, (2024)

[8]

She X, Gao X, Wang K, Et al., Effects of noise and low-concentration carbon monoxide exposure on rat immunity, J Occup Health, 63, (2021)

[9]

Tan P.H., Ellis I, Allison K, Et al., The 2019 WHO classification of tumours of the breast, Histopathology, 77, pp. 181-185, (2020)

[10]

Krecko LK, Neuman HB, Greenberg CC, Et al., Validation of the AJCC 8th Edition Breast Cancer Prognostic Staging System in Legacy Alliance Trials (AFT-01), Ann Surg Oncol, 31, pp. 5880-5887, (2024)

← 1 2 →