Causal relationship between branched-chain amino acids and leukemia risk: insights from a two-sample Mendelian randomization study

被引:0
|
作者
Chen, Shupeng [1 ]
He, Guilian [1 ]
Zhang, Meiling [1 ]
Tang, Nana [2 ]
Zeng, Yingjian [2 ]
机构
[1] Jiangxi Univ Chinese Med, Sch Clin Med, Nanchang, Peoples R China
[2] Jiangxi Univ Tradit Chinese Med, Affiliated Hosp, Hematol Dept, Nanchang, Jiangxi, Peoples R China
基金
中国国家自然科学基金;
关键词
Branched-chain amino acids; acute lymphoblastic leukemia; Mendelian randomization; metabolic reprograming; mTOR signaling pathway; immune regulation; personalized therapy; METABOLISM;
D O I
10.1080/16078454.2024.2433904
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
BackgroundBranched-chain amino acids (BCAAs), including leucine, isoleucine, and valine, are essential amino acids involved in protein synthesis, energy metabolism, and immune regulation. While BCAAs are known to influence cancer biology, their role in leukemia remains unclear. This study employs Mendelian randomization (MR) analysis to explore the causal relationship between BCAA levels and four leukemia subtypes: acute myeloid leukemia (AML), acute lymphoblastic leukemia (ALL), chronic lymphocytic leukemia (CLL), and chronic myeloid leukemia (CML).MethodsData from genome-wide association studies (GWAS) were used to select single nucleotide polymorphisms (SNPs) as instrumental variables (IVs) for BCAA levels. The inverse-variance weighted (IVW) method served as the primary analytical approach, with heterogeneity assessed via Cochran's Q test and pleiotropy through MR-Egger intercept. Sensitivity analysis was performed using leave-one-out analysis.ResultsA significant inverse association was observed between total BCAA levels, leucine, valine, and ALL risk. Total BCAA levels showed an odds ratio (OR) of 0.16 (95% CI: 0.05-0.54, p=0.003), leucine 0.17 (95% CI: 0.04-0.61, p=0.007), and valine 0.21 (95% CI: 0.07-0.61, p=0.004). No significant associations were found for AML, CLL, or CML.ConclusionThis study suggests that BCAAs, particularly leucine and valine, may protect against ALL, offering insights into leukemia metabolic regulation and potential targets for prevention and therapy.
引用
收藏
页数:10
相关论文
共 50 条
  • [41] Causal Relationship Between Abortion and Endometriosis: A Bidirectional Two-Sample Mendelian Randomization Study
    Huang, Yan
    Zhang, Deyu
    Zhou, Yingfang
    Peng, Chao
    AMERICAN JOURNAL OF REPRODUCTIVE IMMUNOLOGY, 2025, 93 (03)
  • [42] Association of branched-chain amino acids and risk of three urologic cancers: a Mendelian randomization study
    Huang, Haotian
    Qin, Jiao
    Wen, Zhi
    Wang, Chongjian
    Chen, Caixia
    Liu, Yang
    Li, Hongyuan
    Cao, Song
    Yang, Xuesong
    TRANSLATIONAL CANCER RESEARCH, 2024, 13 (12)
  • [43] Assessing the causal relationship between gut microbiota and diabetic nephropathy: insights from two-sample Mendelian randomization
    Fang, Yipeng
    Zhang, Yunfei
    Liu, Qian
    Zheng, Zenan
    Ren, Chunhong
    Zhang, Xin
    FRONTIERS IN ENDOCRINOLOGY, 2024, 15
  • [44] Study on the causal relationship between educational attainment and delirium: A two-sample Mendelian randomization study
    Wan, Xianjie
    Yu, Hui
    Yang, Mingyi
    Hou, Weikun
    Xie, Jiale
    Xu, Ke
    Ma, Yujie
    Ma, Rui
    Wang, Fan
    Xu, Peng
    HELIYON, 2024, 10 (07)
  • [45] The causal association between asthma and the risk of frailty: A two-sample Mendelian randomization study
    Ning, Pingping
    Mu, Xin
    Guo, Xingzhi
    Zhou, Rong
    Tian, Ge
    Li, Rui
    AGING CLINICAL AND EXPERIMENTAL RESEARCH, 2024, 37 (01)
  • [46] Causal relationship between obesity and meniscal injuries: Two-sample Mendelian randomization
    Deng, Gaung-Hua
    MEDICINE, 2023, 102 (48) : E36510
  • [47] The causal relationship between hypothyroidism and frozen shoulder: A two-sample Mendelian randomization
    Deng, Guanghua
    Wei, Yongkang
    MEDICINE, 2023, 102 (43) : E35650
  • [48] The causal relationship between depression and frozen shoulder: A two-sample Mendelian randomization
    Deng, Guang-hua
    Wei, Yong-kang
    MEDICINE, 2023, 102 (44) : E35556
  • [49] The causal relationship between psoriasis and cancers: a two-sample Mendelian randomization analysis
    Long, Jiaye
    Yang, Miyang
    Pang, Yingrong
    Kang, Hongyan
    Liang, Shuai
    Wang, Du
    FRONTIERS IN ONCOLOGY, 2024, 14
  • [50] Causal relationship between smoking and spinal stenosis: Two-sample Mendelian randomization
    Deng, Guang-Hua
    MEDICINE, 2024, 103 (38)