Acute Necrotizing Fasciitis Caused by Rhizopus Infection in a Patient with Diabetes and Pulmonary Tuberculosis: A Case Report

被引：0

作者：

Huang, Xiaoqing ^{[1
]}

Qiu, Junke ^{[1
]}

Pan, Lei ^{[1
]}

Wang, Caihong ^{[1
]}

Tang, Chuanfeng ^{[2
]}

机构：

[1] Zhejiang Hosp Integrated Tradit Chinese & Western, TB Intens Care Unit, Hangzhou, Zhejiang, Peoples R China

[2] Zhejiang Hosp Integrated Tradit Chinese & Western, Emergency Dept, 208 East Huancheng Rd, Hangzhou 310000, Zhejiang, Peoples R China

来源：

INFECTION AND DRUG RESISTANCE | 2025年 / 18卷

关键词：

Rhizopus infection; acute necrotizing fasciitis; diabetes; case report; MUCORMYCOSIS; DIAGNOSIS; EPIDEMIOLOGY; ZYGOMYCOSIS; MANAGEMENT; DISEASE; FRANCE;

D O I：

10.2147/IDR.S503791

中图分类号：

R51 [传染病];

学科分类号：

100401 ;

摘要：

Background: Zygomycosis, also termed mucormycosis, is a rare yet highly fatal fungal infection caused by Mucorales species, notably Rhizopus spp. Case Presentation: This case study details a 72-year-old man with diabetes, pulmonary tuberculosis, and nephrotic syndrome who developed acute necrotizing fasciitis attributable to R. oryzae. Despite initial empirical antibiotic therapy, the infection progressed rapidly. Metagenomic next-generation sequencing (mNGS) facilitated a swift diagnosis, identifying R. oryzae in blood and drainage samples. The treatment included amphotericin B and isavuconazole, along with aggressive surgical debridement. The patient exhibited substantial improvement, and he was discharged after stabilization. Conclusion: This case highlights the critical role of early diagnosis through mNGS and the need for a multidisciplinary approach to manage severe mucormycosis in immunocompromised patients.

引用

页码：775 / 782

页数：8

共 31 条

[1] Population-Based Analysis of Invasive Fungal Infections, France, 2001-2010 [J].

Bitar, Dounia ;

Lortholary, Olivier ;

Le Strat, Yann ;

Nicolau, Javier ;

Coignard, Bruno ;

Tattevin, Pierre ;

Che, Didier ;

Dromer, Francoise .

EMERGING INFECTIOUS DISEASES, 2014, 20 (07) :1149-1155

[2] Increasing Incidence of Zygomycosis (Mucormycosis), France, 1997-2006 [J].

Bitar, Dounia ;

Van Cauteren, Dieter ;

Lanternier, Fanny ;

Dannaoui, Eric ;

Che, Didier ;

Dromer, Francoise ;

Desenclos, Jean-Claude ;

Lortholary, Olivier .

EMERGING INFECTIOUS DISEASES, 2009, 15 (09) :1395-1401

[3] Airway necrosis and granulation tissue formation caused by Rhizopus oryzae leading to severe upper airway obstruction: a case report [J].

Chen, Geng-Jia ;

Chen, Xiao-Bo ;

Rao, Wan-Yuan ;

Pan, Xiao-Yi ;

Li, Shi-Yue ;

Su, Zhu-Quan .

FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY, 2024, 14

[4]

Chen Leon L, 2020, Nursing, V50, P34, DOI 10.1097/01.NURSE.0000694752.85118.62

[5] Global guideline for the diagnosis and management of mucormycosis: an initiative of the European Confederation of Medical Mycology in cooperation with the Mycoses Study Group Education and Research Consortium [J].

Cornely, Oliver A. ;

Alastruey-Izquierdo, Ana ;

Arenz, Dorothee ;

Chen, Sharon C. A. ;

Dannaoui, Eric ;

Hochhegger, Bruno ;

Hoenigl, Martin ;

Jensen, Henrik E. ;

Lagrou, Katrien ;

Lewis, Russell E. ;

Mellinghoff, Sibylle C. ;

Mer, Mervyn ;

Pana, Zoi D. ;

Seidel, Danila ;

Sheppard, Donald C. ;

Wahba, Roger ;

Akova, Murat ;

Alanio, Alexandre ;

Al-Hatmi, Abdullah M. S. ;

Arikan-Akdagli, Sevtap ;

Badali, Hamid ;

Ben-Ami, Ronen ;

Bonifaz, Alexandro ;

Bretagne, Stephane ;

Castagnola, Elio ;

Chayakulkeeree, Methee ;

Colombo, Arnaldo L. ;

Corzo-Leon, Dora E. ;

Drgona, Lubos ;

Groll, Andreas H. ;

Guinea, Jesus ;

Heussel, Claus-Peter ;

Ibrahim, Ashraf S. ;

Kanj, Souha S. ;

Klimko, Nikolay ;

Lackner, Michaela ;

Lamoth, Frederic ;

Lanternier, Fanny ;

Lass-Floerl, Cornelia ;

Lee, Dong-Gun ;

Lehrnbecher, Thomas ;

Lmimouni, Badre E. ;

Mares, Mihai ;

Maschmeyer, Georg ;

Meis, Jacques F. ;

Meletiadis, Joseph ;

Morrissey, C. Orla ;

Nucci, Marcio ;

Oladele, Rita ;

Pagano, Livio .

LANCET INFECTIOUS DISEASES, 2019, 19 (12) :E405-E421

[6] Diabetes mellitus as the major risk factor for mucormycosis in Mexico: Epidemiology, diagnosis, and outcomes of reported cases [J].

Corzo-Leon, Dora E. ;

Chora-Hernandez, Luis D. ;

Rodriguez-Zulueta, Ana P. ;

Walsh, Thomas J. .

MEDICAL MYCOLOGY, 2018, 56 (01) :29-43

[7] Successful isavuconazole salvage therapy in a patient with invasive mucormycosis [J].

Ervens, J. ;

Ghannoum, M. ;

Graf, B. ;

Schwartz, S. .

INFECTION, 2014, 42 (02) :429-432

[8]

Guilu T, 2021, Chin J Postgraduates Med, V44, P1025

[9] Necrotizing Fasciitis and The Diabetic Foot [J].

Iacopi, Elisabetta ;

Coppelli, Alberto ;

Goretti, Chiara ;

Piaggesi, Alberto .

INTERNATIONAL JOURNAL OF LOWER EXTREMITY WOUNDS, 2015, 14 (04) :316-327

[10] Caspofungin inhibits rhizopus oryzae 1,3-β-D-glucan synthase, lowers burden in brain measured by quantitative PCR, and improves survival at a low but not a high dose during murine disseminated zygomycosis [J].

Ibrahim, AS ;

Bowman, JC ;

Avanessian, V ;

Brown, K ;

Spellberg, B ;

Edwards, JE ;

Douglas, CM .

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 2005, 49 (02) :721-727

← 1 2 3 4 →