Advancements in Microphysiological systems: Exploring organoids and organ-on-a-chip technologies in drug development -focus on pharmacokinetics related organs-

被引：2

作者：

Kimura, Hiroshi ^{[1
]}

Nishikawa, Masaki ^{[2
]}

Kutsuzawa, Naokata ^{[1
,3
]}

Tokito, Fumiya ^{[2
]}

Kobayashi, Takuma ^{[2
]}

Kurniawan, Dhimas Agung ^{[2
]}

Shioda, Hiroki ^{[2
]}

Cao, Wenxin ^{[2
]}

Shinha, Kenta ^{[1
]}

Nakamura, Hiroko ^{[1
]}

Doi, Kotaro ^{[4
]}

Sakai, Yasuyuki ^{[2
]}

机构：

[1] Tokai Univ, Micro Nano Technol Ctr, 4-1-1 Kitakaname, Hiratsuka, Kanagawa 2591292, Japan

[2] Univ Tokyo, Grad Sch Engn, Dept Chem Syst Engn, 7-3-1 Hongo,Bunkyo Ku, Tokyo 1138654, Japan

[3] Tokai Univ, Sch Med, Dept Med, Sch Med, 143 Shimokasuya, Isehara, Kanagawa 2591143, Japan

[4] Univ Tokyo Hosp, Div Nephrol & Endocrinol, 7-3-1 Hongo,Bunkyo Ku, Tokyo 1138655, Japan

来源：

DRUG METABOLISM AND PHARMACOKINETICS | 2025年 / 60卷

关键词：

Microphysiological systems; Organoid; Organ-on-a-chip; Alternatives to animal testing; Drug development; INTESTINAL EPITHELIAL-CELLS; IN-VITRO; KIDNEY ORGANOIDS; BASEMENT-MEMBRANE; SHEAR-STRESS; MODEL; LIVER; DISEASE; DIFFERENTIATION; METABOLISM;

D O I：

10.1016/j.dmpk.2024.101046

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

This study explored the evolving landscape of Microphysiological Systems (MPS), with a focus on organoids and organ-on-a-chip (OoC) technologies, which are promising alternatives to animal testing in drug discovery. MPS technology offers in vitro models with high physiological relevance, simulating organ function for pharmacokinetic studies. Organoids composed of 3D cell aggregates and OoCs mimicking in vivo environments based on microfluidic platforms represent the forefront of MPS. This paper provides a comprehensive overview of their application in studying the gut, liver, and kidney and their challenges in becoming reliable alternatives to in vivo models. Although MPS technology is not yet fully comparable to in vivo systems, its continued development, aided by in silico, automation, and AI approaches, is anticipated to bring about further advancements. Collaboration across multiple disciplines and ongoing regulatory discussions will be crucial in driving MPS toward practical and ethical applications in biomedical research and drug development.

引用

页数：19

共 3 条

[1] 3D organ-on-a-chip: The convergence of microphysiological systems and organoids
Baptista, Leandra S.
Porrini, Constance
Kronemberger, Gabriela S.
Kelly, Daniel J.
Perrault, Cecile M.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY, 2022, 10
[2] Organ-on-a-chip technologies for biomedical research and drug development: A focus on the vasculature
Veliz, Diosangeles Soto
Lin, Kai-Lan
Sahlgren, Cecilia
SMART MEDICINE, 2023, 2 (01):
[3] 3D organ-on-a-chip: the convergence of microphysiological systems and organoids (vol 10, 1043117, 2022)
Baptista, Leandra S.
Porrini, Constance
Kronemberger, Gabriela S.
Kelly, Daniel J.
Perrault, Cecile M.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY, 2024, 12

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