The Role of Fatty Acid Metabolism, the Related Potential Biomarkers, and Targeted Therapeutic Strategies in Gastrointestinal Cancers

被引：0

作者：

Xie, Ruixi ^{[1
]}

Luo, Ying ^{[1
]}

Bao, Bowen ^{[1
]}

Wu, Xinshu ^{[1
]}

Guo, Jia ^{[1
]}

Wang, Jin ^{[1
]}

Qu, Xiujuan ^{[1
]}

Che, Xiaofang ^{[1
]}

Zheng, Chunlei ^{[1
,2
]}

机构：

[1] China Med Univ, Hosp 1, Clin Canc Res Ctr Shenyang, Dept Med Oncol,Prov Key Lab Anticanc Drugs & Bioth, Shenyang, Liaoning, Peoples R China

[2] Shanghai Elect Power Hosp, Dept Oncol, Shanghai, Peoples R China

来源：

DRUG DEVELOPMENT RESEARCH | 2024年 / 85卷 / 07期

基金：

中国国家自然科学基金;

关键词：

anticancer strategies; biomarkers; fatty acid metabolism; gastrointestinal cancer; lipidomic; STEAROYL-COA DESATURASE; SOLUBLE EPOXIDE HYDROLASE; PHASE-I TRIAL; HEPATOCELLULAR-CARCINOMA; COLORECTAL-CANCER; ARACHIDONIC-ACID; COLON-CANCER; GREEN TEA; PRECLINICAL EVALUATION; LIPID-METABOLISM;

D O I：

10.1002/ddr.70014

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Gastrointestinal cancer has emerged as a significant global health concern due to its high incidence and mortality, limited effectiveness of early detection, suboptimal treatment outcomes, and poor prognosis. Metabolic reprogramming is a prominent feature of cancer, and fatty acid metabolism assumes a pivotal role in bridging glucose metabolism and lipid metabolism. Fatty acids play important roles in cellular structural composition, energy supply, signal transduction, and other lipid-related processes. Changes in the levels of fatty acid metabolite may indicate the malignant transformation of gastrointestinal cells, which have an impact on the prognosis of patients and can be used as a marker to monitor the efficacy of anticancer therapy. Therefore, targeting key enzymes involved in fatty acid metabolism, either as monotherapy or in combination with other agents, is a promising strategy for anticancer treatment. This article reviews the potential mechanisms of fatty acid metabolism disorders in the occurrence and development of gastrointestinal tumors, and summarizes the related potential biomarkers and anticancer strategies.

引用

页数：19

共 179 条

[1] Consumption of Fish and Long-chain n-3 Polyunsaturated Fatty Acids Is Associated With Reduced Risk of Colorectal Cancer in a Large European Cohort [J].

Aglago, Elom K. ;

Huybrechts, Inge ;

Murphy, Neil ;

Casagrande, Corinne ;

Nicolas, Genevieve ;

Pischon, Tobias ;

Fedirko, Veronika ;

Severi, Gianluca ;

Boutron-Ruault, Marie-Christine ;

Fournier, Agnes ;

Katzke, Verena ;

Kuehn, Tilman ;

Olsen, Anja ;

Tjonneland, Anne ;

Dahm, Christina C. ;

Overvad, Kim ;

Lasheras, Cristina ;

Agudo, Antonio ;

Sanchez, Maria-Jose ;

Amiano, Pilar ;

Maria Huerta, Jose ;

Ardanaz, Eva ;

Perez-Cornago, Aurora ;

Trichopoulou, Antonia ;

Karakatsani, Anna ;

Martimianaki, Georgia ;

Palli, Domenico ;

Pala, Valeria ;

Tumino, Rosario ;

Naccarati, Alessio ;

Panico, Salvatore ;

Bueno-de-Mesquita, Bas ;

May, Anne ;

Derksen, Jeroen W. G. ;

Hellstrand, Sophie ;

Ohlsson, Bodil ;

Wennberg, Maria ;

Van Guelpen, Bethany ;

Skeie, Guri ;

Brustad, Magritt ;

Weiderpass, Elisabete ;

Cross, Amanda J. ;

Ward, Heather ;

Riboli, Elio ;

Norat, Teresa ;

Chajes, Veronique ;

Gunter, Marc J. .

CLINICAL GASTROENTEROLOGY AND HEPATOLOGY, 2020, 18 (03) :654-+

[2] A Low Dietary Ratio of Omega-6 to Omega-3 Fatty Acids May Delay Progression of Prostate Cancer [J].

Apte, Shruti A. ;

Cavazos, David A. ;

Whelan, Kaitlin A. ;

deGraffenried, Linda A. .

NUTRITION AND CANCER-AN INTERNATIONAL JOURNAL, 2013, 65 (04) :556-562

[3] The Mitochondrial Disruptor Devimistat (CPI-613) Synergizes with Genotoxic Anticancer Drugs in Colorectal Cancer Therapy in a Bim-Dependent Manner [J].

Arnold, Carina ;

Demuth, Philipp ;

Seiwert, Nina ;

Wittmann, Simon ;

Boengler, Kerstin ;

Rasenberger, Birgit ;

Christmann, Markus ;

Huber, Magdalena ;

Brunner, Thomas ;

Linnebacher, Michael ;

Fahrer, Joerg .

MOLECULAR CANCER THERAPEUTICS, 2022, 21 (01) :100-112

[4] Arachidonic Acid-metabolizing Cytochrome P450 Enzymes Are Targets of ω-3 Fatty Acids [J].

Arnold, Cosima ;

Markovic, Marija ;

Blossey, Katrin ;

Wallukat, Gerd ;

Fischer, Robert ;

Dechend, Ralf ;

Konkel, Anne ;

von Schacky, Clemens ;

Luft, Friedrich C. ;

Muller, Dominik N. ;

Rothe, Michael ;

Schunck, Wolf-Hagen .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2010, 285 (43) :32720-32733

[5] Arachidonic acid activates a functional AP-1 and an inactive NF-κB complex in human HepG2 hepatoma cells [J].

Bécuwe, P ;

Bianchi, A ;

Didelot, C ;

Barberi-Heyob, M ;

Dauça, M .

FREE RADICAL BIOLOGY AND MEDICINE, 2003, 35 (06) :636-647

[6] Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of a Liver-Targeting Acetyl-CoA Carboxylase Inhibitor (PF-05221304): A Three-Part Randomized Phase 1 Study [J].

Bergman, Arthur ;

Carvajal-Gonzalez, Santos ;

Tarabar, Sanela ;

Saxena, Aditi R. ;

Esler, William R. ;

Amin, Neeta B. .

CLINICAL PHARMACOLOGY IN DRUG DEVELOPMENT, 2020, 9 (04) :514-526

[7] A phase I trial of the HIV protease inhibitor nelfinavir in adults with solid tumors [J].

Blumenthal, Gideon M. ;

Gills, Joell J. ;

Ballas, Marc S. ;

Bernstein, Wendy B. ;

Komiya, Takefumi ;

Dechowdhury, Roopa ;

Morrow, Betsy ;

Root, Hyejeong ;

Chun, Guinevere ;

Helsabeck, Cynthia ;

Steinberg, Seth M. ;

LoPiccolo, Jaclyn ;

Kawabata, Shigeru ;

Gardner, Erin R. ;

Figg, William D. ;

Dennis, Phillip A. .

ONCOTARGET, 2014, 5 (18) :8161-8172

[8] Heterogeneity of Cancer Stem Cells: Rationale for Targeting the Stem Cell Niche [J].

Boesch, Maximilian ;

Sopper, Sieghart ;

Zeimet, Alain G. ;

Reimer, Daniel ;

Gastl, Guenther ;

Ludewig, Burkhard ;

Wolf, Dominik .

BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER, 2016, 1866 (02) :276-289

[9]

Bonnefont Jean-Paul, 2004, Molecular Aspects of Medicine, V25, P495, DOI 10.1016/j.mam.2004.06.004

[10] Metformin plus lrinotecan in patients with refractory colorectal cancer: a phase 2 clinical trial [J].

Bragagnoli, Arinilda Campos ;

Araujo, Raphael L. C. ;

Ferraz, Mauricio Wagner ;

dos Santos, Lucas Vieira ;

Abdalla, Kathia Cristina ;

Comar, Fabiana ;

Santos, Florinda Almeida ;

Oliveira, Marco Antonio ;

Campello Carvalheira, Jose Barreto ;

Carcano, Flavio Mavigner ;

da Silveira Nogueira Lima, Joao Paulo .

BRITISH JOURNAL OF CANCER, 2021, 124 (06) :1072-1078

← 1 2 3 4 5 6 7 8 9 10 →