Drip fertigation (DF) can improve yield, water use efficiency (WUE), and nitrogen use efficiency (NUE, grain production per unit of the sum of soil inherent mineral N and fertilizer N), as well as reduce the risk of environmental pollution compared with flood irrigation and N fertilizer broadcast (FB). Previously, we showed that DF enhanced the response of the yield to the N topdressing rate (NTR), but the underlying mechanisms associated with the soil N supply, root architecture, and N uptake remain unclear. We conducted a field experiment by testing six N treatments (no N applied, and NTRs of 0, 40, 80, 120, and 160 kg ha-1, denoted as N0, T0, T40, T80, T120, and T160, respectively) under DF and FB from 2021 to 2023. Compared with FB, the NUE and WUE were 4.8-4.9% and 10.0-10.5% higher under DF. The higher NUE was due to an improvement in N uptake efficiency (6.1-7.7%) resulting from the enhanced aboveground N uptake (AGN). The greater AGN under DF was attributed to the higher soil N availability at the soil depth of 0-40 cm. DF decreased the residual soil NO3--N at a depth of 40-200 cm but increased the NO3--N at a depth of 0-40 cm. In addition, DF combined with T80 achieved high root length density, surface density, and dry weight density and improved NUE and WUE. DF combined with T80 achieved high yield and efficient utilization of water and N, and the NTR threshold was 61.75-119.50 kg ha-1, in which the production conditions were similar to those of the experimental site. Our results provide a reference for high-efficiency water and N fertilizer usage for irrigated winter wheat production in North China.