Clonal Hematopoiesis in Women With Breast Cancer

被引：1

作者：

Mayerhofer, Christina ^{[1
,2
,3
]}

Freedman, Rachel A. ^{[4
,5
,6
]}

Parsons, Heather A. ^{[3
,4
,5
,6
]}

Partridge, Ann H. ^{[4
,5
,6
]}

Miller, Peter G. ^{[3
,4
,7
]}

机构：

[1] Harvard Stem Cell Inst, Dept Stem Cell & Regenerat Biol, Cambridge, MA USA

[2] Massachusetts Gen Hosp, Ctr Regenerat Med, Boston, MA USA

[3] Broad Inst Massachusetts Inst Technol & Harvard Un, Cambridge, MA 02114 USA

[4] Harvard Med Sch, Boston, MA 02115 USA

[5] Dana Farber Canc Inst, Med Oncol, Boston, MA USA

[6] Dana Farber Brigham Canc Ctr, Breast Oncol Program, Boston, MA USA

[7] Massachusetts Gen Hosp, Ctr Canc Res, Boston, MA 02114 USA

来源：

JOURNAL OF CLINICAL ONCOLOGY | 2025年 / 43卷 / 07期

关键词：

RISK; THERAPY; INFLAMMATION; MUTATIONS; COMMON; TET2; NEOPLASMS; CELLS;

D O I：

10.1200/JCO-24-01848

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

PURPOSEClonal hematopoiesis (CH) has been associated with a variety of adverse outcomes, most notably hematologic malignancy and ischemic cardiovascular disease. A series of recent studies also suggest that CH may play a role in the outcomes of patients with solid tumors, including breast cancer. Here, we review the clinical and biological data that underlie potential connections between CH, inflammation, and breast cancer, with a focus on the prevalence and impact of clonal hematopoiesis of indeterminate potential in patients with breast cancer.METHODSWe summarize data from multiple studies, including a series of cohorts of patients with breast cancer, to assess the prevalence of CH, the relationship between CH and exposure to cytotoxic therapy, and the correlation between CH and breast cancer-specific outcomes.RESULTSOur findings indicate that CH is prevalent among patients with breast cancer, particularly those treated with cytotoxic therapies. However, there are no definitive data to support an association between the presence of CH and breast cancer-specific outcomes.CONCLUSIONCurrent data do not support routine CH testing in patients with breast cancer, nor should the presence of CH influence decisions regarding breast cancer therapy in most patients. However, larger, long-term studies are necessary to further define the implications of CH in patients with breast cancer and guide clinical decision making.

引用

页数：8

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