Study insights in the role of PGC-1α in neurological diseases: mechanisms and therapeutic potential

被引：0
作者：
Tang, Mi-bo [1 ]
Liu, Yi-xuan [1 ]
Hu, Zheng-wei [2 ]
Luo, Hai-yang [2 ]
Zhang, Shuo [2 ]
Shi, Chang-he [2 ]
Xu, Yu-ming [2 ,3 ,4 ]
机构：
[1] Zhengzhou Univ, Affiliated Hosp 1, Dept Geriatr, Zhengzhou, Peoples R China
[2] Zhengzhou Univ, Affiliated Hosp 1, Dept Neurol, Zhengzhou, Peoples R China
[3] NHC Key Lab Prevent & Treatment Cerebrovascular Di, Zhengzhou, Henan, Peoples R China
[4] Zhengzhou Univ, Henan Key Lab Cerebrovascular Dis, Zhengzhou, Henan, Peoples R China
来源：
FRONTIERS IN AGING NEUROSCIENCE | 2025年 / 16卷
基金：
中国国家自然科学基金;
关键词：
PGC-1; alpha; mitochondria; neuroinflammation; oxidative stress; neurological diseases; SPINAL-CORD-INJURY; MITOCHONDRIAL BIOGENESIS; OXIDATIVE STRESS; HUNTINGTONS-DISEASE; ALZHEIMERS-DISEASE; MOUSE MODEL; PARKINSONS-DISEASE; GABAERGIC NEURONS; GLOBAL-ISCHEMIA; SOD1(G93A) ALS;
D O I：
10.3389/fnagi.2024.1454735
中图分类号：
R592 [老年病学]; C [社会科学总论];
学科分类号：
03 ; 0303 ; 100203 ;
摘要：
Peroxisome proliferator-activated receptor-gamma coactivator-1 alpha (PGC-1 alpha), which is highly expressed in the central nervous system, is known to be involved in the regulation of mitochondrial biosynthesis, metabolic regulation, neuroinflammation, autophagy, and oxidative stress. This knowledge indicates a potential role of PGC-1 alpha in a wide range of functions associated with neurological diseases. There is emerging evidence indicating a protective role of PGC-1 alpha in the pathogenesis of several neurological diseases. As such, a deeper and broader understanding of PGC-1 alpha and its role in neurological diseases is urgently needed. The present review provides a relatively complete overview of the current knowledge on PGC-1 alpha, including its functions in different types of neurons, basic structural characteristics, and its interacting transcription factors. Furthermore, we present the role of PGC-1 alpha in the pathogenesis of various neurological diseases, such as intracerebral hemorrhage, ischemic stroke, Alzheimer's disease, Parkinson's disease, Amyotrophic lateral sclerosis, Huntington's disease, and other PolyQ diseases. Importantly, we discuss some compounds or drug-targeting strategies that have been studied to ameliorate the pathology of these neurological diseases and introduce the possible mechanistic pathways. Based on the available studies, we propose that targeting PGC-1 alpha could serve as a promising novel therapeutic strategy for one or more neurological diseases.
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页数：12
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