The role of TREM2 in myelin sheath dynamics: A comprehensive perspective from physiology to pathology

被引：0

作者：

Que, Xinwei ^{[1
,2
,3
,4
]}

Zhang, Tongtong ^{[1
,2
,3
]}

Liu, Xueyu ^{[1
,2
,3
]}

Yin, Yunsi ^{[1
,2
,3
]}

Xia, Xinyi ^{[1
,2
,3
]}

Gong, Ping ^{[4
]}

Song, Weiyi ^{[1
,2
,3
,4
]}

Qin, Qi ^{[1
,2
,3
]}

Xu, Zhi-Qing David ^{[4
]}

Tang, Yi ^{[1
,2
,3
]}

机构：

[1] Capital Med Univ, Xuanwu Hosp, Dept Neurol, Natl Ctr Neurol Disorders, Beijing 100053, Peoples R China

[2] Capital Med Univ, Xuanwu Hosp, Innovat Ctr Neurol Disorders, Natl Ctr Neurol Disorders, Beijing 100053, Peoples R China

[3] Minist Educ Peoples Republ China, Neurodegenerat Lab, Beijing 100053, Peoples R China

[4] Capital Med Univ, Dept Neurobiol & Pathol, Beijing 100069, Peoples R China

来源：

PROGRESS IN NEUROBIOLOGY | 2025年 / 247卷

基金：

中国国家自然科学基金;

关键词：

TREM2; Myelin; Demyelination; Microglia; AMYLOID-BETA DEPOSITION; NASU-HAKOLA DISEASE; MULTIPLE-SCLEROSIS; M2; MICROGLIA; CLEARANCE; CHOLESTEROL; MACROPHAGES; ACTIVATION; IMMUNE; CELLS;

D O I：

10.1016/j.pneurobio.2025.102732

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Demyelinating disorders, characterizing by the loss of myelin integrity, present significant challenges due to their impact on neurological function and lack of effective treatments. Understanding the mechanisms underlying myelin damage is crucial for developing therapeutic strategies. Triggering receptor expressed on myeloid cells 2 (TREM2), a pivotal immune receptor predominantly found on microglial cells, plays essential roles in phagocytosis and lipid metabolism, vital processes in neuroinflammation and immune regulation. Emerging evidence indicates a close relationship between TREM2 and various aspects of myelin sheath dynamics, including maintenance, response to damage, and regeneration. This review provides a comprehensive discussion of TREM2's influence on myelin physiology and pathology, highlighting its therapeutic potential and putative mechanisms in the progression of demyelinating disorders.

引用

页数：12

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