Colorectal liver metastases on gadoxetic acid-enhanced MRI: Typical characteristics decrease after chemotherapy

被引：0

作者：

van der Reijd, Denise J. ^{[1
,2
]}

Soykan, Ezgi A. ^{[1
,3
]}

Heeres, Birthe C. ^{[1
]}

Lambregts, Doenja M. J. ^{[1
,2
]}

Vollebergh, Marieke A. ^{[4
]}

Kuhlmann, Koert F. D. ^{[5
]}

Kok, Niels F. M. ^{[5
]}

Snaebjornsson, Petur ^{[6
,7
]}

Beets-Tan, Regina G. H. ^{[1
,8
]}

Maas, Monique ^{[1
,2
]}

Klompenhouwer, Elisabeth G. ^{[1
]}

机构：

[1] Antoni van Leeuwenhoek Netherlands Canc Inst, Dept Radiol, Amsterdam, Netherlands

[2] Maastricht Univ, GROW Sch Oncol & Reprod, Maastricht, Netherlands

[3] Univ Amsterdam, Canc Ctr Amsterdam, Dept Radiol & Nucl Med, Amsterdam UMC, Amsterdam, Netherlands

[4] Antoni Van Leeuwenhoek Netherlands Canc Inst, Dept Gastrointestinal Oncol, Amsterdam, Netherlands

[5] Antoni van Leeuwenhoek Netherlands Canc Inst, Dept Surg Oncol, Amsterdam, Netherlands

[6] Antoni van Leeuwenhoek Netherlands Canc Inst, Dept Pathol, Amsterdam, Netherlands

[7] Univ Iceland, Fac Med, Reykjavik, Iceland

[8] Univ Southern Denmark, Inst Reg Hlth Res, Odense, Denmark

来源：

CLINICAL IMAGING | 2025年 / 119卷

关键词：

Magnetic resonance imaging; Liver; Colorectal cancer; Metastasis; Gadoxetic acid; Chemotherapy; GD-EOB-DTPA; PERILESIONAL ENHANCEMENT; HEPATIC METASTASES; CT; ACCURACY; IMPACT;

D O I：

10.1016/j.clinimag.2025.110417

中图分类号：

R8 [特种医学]; R445 [影像诊断学];

学科分类号：

1002 ; 100207 ; 1009 ;

摘要：

Purpose: To determine to what extent colorectal liver metastases (CRLM) display typical imaging characteristics on gadoxetic acid-enhanced magnetic resonance imaging (MRI) and what changes after chemotherapy. Methods: We retrospectively identified 258 patients with a gadoxetic acid-enhanced MRI between 2015 and 2021 and pathologically proven non-mucinous adenocarcinoma CRLM. 722 unique CRLMs were analyzed: 378 CRLM in only the chemotherapy-na & iuml;ve analysis; 217 in post-chemotherapy analysis; and 127 CRLM were analyzed both pre- and post-chemotherapy. The following six characteristics were defined as typical; "hypovascular", "unenhanced T1-weighted (UE-T1W) hypointensity", "arterial rim enhancement", "non-enhancing during hepatobiliary phase", "T2-weighted (T2W) mild hyperintensity", and "diffusion restriction". Results: All six typical characteristics were found in 249/505 chemotherapy-na & iuml;ve CRLM (49 %) and 87/344 post- chemotherapy CRLM (25 %). The occurrence of some typical characteristics decreased post-chemotherapy: UET1W hypointensity 485/505 (96 %) versus 311/336 (93 %), arterial rim enhancement 291/498 (58 %) versus 154/301 (51 %), T2W mild hyperintensity 478/505 (95 %) versus 269/338 (79 %), and diffusion restriction 435/497 (87 %) versus 200/306 (65 %). Almost all metastases showed a hypovascular appearance, both in the chemotherapy-na & iuml;ve (495/504, 98 %) and post-chemotherapy group (330/331, 100 %). Additionally, all CRLM appeared non-enhancing compared to the liver in the hepatobiliary phase (100 %). Conclusion: Most CRLM show various combinations of at least five typical characteristics on gadoxetic acid- enhanced MRI. Arterial rim enhancement is the least prevalent characteristic both in chemotherapy-na & iuml;ve and post-chemotherapy patients. Post-chemotherapy the occurrence of typical MRI characteristics decreases, especially mild T2W hyperintensity and the presence of diffusion restriction.

引用

页数：7

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