Glycolytic reprogramming in microglia: A potential therapeutic target for ischemic stroke

被引：1
作者：
Zhang, Guangming [1 ]
Zhao, Anliu [1 ]
Zhang, Xiaolu [1 ]
Zeng, Miao [1 ]
Wei, Huayuan [1 ]
Yan, Xu [1 ]
Wang, Jie [1 ]
Jiang, Xijuan [1 ]
Dai, Yongna [2 ]
机构：
[1] Tianjin Univ Tradit Chinese Med, Sch Integrat Med, Tianjin 301617, Peoples R China
[2] Tianjin Univ Tradit Chinese Med, Sch Tradit Chinese Med, Tianjin 301617, Peoples R China
来源：
CELLULAR SIGNALLING | 2024年 / 124卷
基金：
中国国家自然科学基金;
关键词：
Ischemic stroke; Microglia; Polarization; Glycolysis; Neuroinflammation; HEXOKINASE; 2; METABOLISM; EXPRESSION; PKM2; ACTIVATION; REGULATOR; INJURY; NEUROINFLAMMATION; NEUROPROTECTION; DISTURBANCES;
D O I：
10.1016/j.cellsig.2024.111466
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
Ischemic stroke is currently the second leading cause of mortality worldwide, with limited treatment options available. As resident immune cells, microglia promptly respond to cerebral ischemic injury, influencing neuroinflammatory damage and neurorepair. Studies suggest that microglia undergo metabolic reprogramming from mitochondrial oxidative phosphorylation to glycolysis in response to ischemia, significantly impacting their function during ischemic stroke. Therefore, this study aims to investigate the roles and regulatory mechanisms involved in this process, aiming to identify a new therapeutic target or potential drug candidate.
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页数：17
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