Associations of haematological and inflammatory biomarkers with brain volume in patients with sickle cell anaemia: A cross-sectional retrospective study

被引：0
作者：
Majrashi, Naif A. [1 ]
Hendi, Ali M. [1 ,2 ]
Dhayihi, Turki M. [1 ,2 ]
Khamesi, Abdullah M. [3 ]
Masmali, Mohammed A. [4 ]
Hakami, Khalid J. [4 ]
Alyami, Ali S. [1 ]
Alwadani, Bandar [1 ]
Ageeli, Wael A. [1 ]
Madkhali, Yahia [1 ]
Hakamy, Ali [5 ]
Refaee, Turkey A. [1 ]
机构：
[1] Jazan Univ, Fac Nursing & Hlth Sci, Diagnost Radiog Technol DRT Dept, Jazan, Saudi Arabia
[2] Jazan Univ, Fac Med, Dept Radiol, Jazan, Saudi Arabia
[3] Jazan Hlth Cluster, Jazan Specialist Hosp, Radiol Dept, Jazan, Saudi Arabia
[4] Jazan Hlth Affairs, King Fahad Cent Hosp, Minist Hlth, Radiol Dept, Jazan, Saudi Arabia
[5] Jazan Univ, Fac Nursing & Hlth Sci, Resp Therapy Dept, Jazan, Saudi Arabia
来源：
TROPICAL MEDICINE & INTERNATIONAL HEALTH | 2024年 / 29卷 / 12期
关键词：
brain volume; cortical; FreeSurfer; haematological; inflammatory biomarkers; MRI; sickle cell anaemia; SEX-DIFFERENCES; DISEASE; HEMOGLOBIN; SIZE; PARAMETERS; MRI;
D O I：
10.1111/tmi.14056
中图分类号：
R1 [预防医学、卫生学];
学科分类号：
1004 ; 120402 ;
摘要：
Sickle cell disease is a genetic disorder characterised by abnormal haemoglobin production. This study aims to investigate the associations between haematological and inflammatory biomarkers and brain volumes in patients with sickle cell anaemia and compare brain structure between patients with sickle cell anaemia and healthy controls. This retrospective cross-sectional study included 130 participants (70 sickle cell anaemia patients and 60 healthy controls) who underwent brain MRI examinations at King Fahad Central Hospital between January 2010 and October 2022. Demographic data and haematological and inflammatory biomarkers were collected to examine their relationships with brain volumes. Brain volumes were measured using FreeSurfer. Specific haematological and inflammatory biomarkers were correlated with brain volume in patients with sickle cell anaemia, p < 0.05. Sickle cell anaemia patients exhibited smaller volumes in the brainstem, corpus callosum and amygdala compared to healthy controls. Males had significantly higher iron levels (p < 0.001) and larger various brain structure volumes (p < 0.05) than females. This study demonstrates significant associations between specific biomarkers and brain volume in sickle cell anaemia patients, underscoring the importance of monitoring these biomarkers for early detection and management of neurological complications in sickle cell anaemia.
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收藏
页码：1026 / 1040
页数：15
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