A systematic review of the predictive factors for the recurrence of acute pancreatitis

被引：0

作者：

Daniela Pacella ^{[1
]}

Adriano De Simone ^{[1
]}

Adolfo Pisanu ^{[17
]}

Gianluca Pellino ^{[2
]}

Lucio Selvaggi ^{[3
]}

Valentina Murzi ^{[3
]}

Eleonora Locci ^{[2
]}

Giulia Ciabatti ^{[2
]}

Laura Mastrangelo ^{[4
]}

Elio Jovine ^{[4
]}

Matteo Rottoli ^{[4
]}

Giacomo Calini ^{[6
]}

Stefano Cardelli ^{[16
]}

Fausto Catena ^{[6
]}

Carlo Vallicelli ^{[6
]}

Raffaele Bova ^{[16
]}

Gabriele Vigutto ^{[12
]}

Fabrizio D’Acapito ^{[12
]}

Giorgio Ercolani ^{[12
]}

Leonardo Solaini ^{[12
]}

Alan Biloslavo ^{[5
]}

Paola Germani ^{[5
]}

Camilla Colutta ^{[5
]}

Pasquale Lepiane ^{[7
]}

Rosa Scaramuzzo ^{[7
]}

Savino Occhionorelli ^{[7
]}

Domenico Lacavalla ^{[8
]}

Maria Grazia Sibilla ^{[8
]}

Stefano Olmi ^{[11
]}

Matteo Uccelli ^{[11
]}

Alberto Oldani ^{[11
]}

Alessio Giordano ^{[10
]}

Tommaso Guagni ^{[10
]}

Davina Perini ^{[10
]}

Francesco Pata ^{[9
]}

Bruno Nardo ^{[9
]}

Daniele Paglione ^{[9
]}

Giusi Franco ^{[14
]}

Matteo Donadon ^{[14
]}

Marcello Di Martino ^{[14
]}

Salomone Di Saverio ^{[14
]}

Luca Cardinali ^{[13
]}

Grazia Travaglini ^{[13
]}

Dario Bruzzese ^{[15
]}

Mauro Podda ^{[15
]}

机构：

[1] Department of Public Health, University of Naples Federico II, Naples

[2] Emergency Surgery Unit, Department of Surgical Science, University of Cagliari, Cagliari

[3] Department of Advanced Medical and Surgical Sciences, University of Campania “Luigi Vanvitelli”, Naples

[4] Department of Medical and Surgical Science, University of Bologna, Maggiore Hospital, Bologna

[5] Department of Medical and Surgical Science, University of Bologna, Morgagni-Pierantoni Hospital Forlì, Forlì

[6] Department of Medical and Surgical Science, University of Bologna, Sant’Orsola Hospital, Bologna

[7] Department of General Surgery, Azienda Sanitaria Universitaria Giuliano Isontina, University of Trieste, Trieste

[8] Department of Surgery, San Paolo Hospital Civitavecchia, Rome

[9] Department of Emergency Surgery, Careggi Hospital, Firenze

[10] Department of General Surgery, San Donato Hospital Zingonia, Bergamo

[11] Department of Morphology, Surgery and Experimental Medicine, University of Ferrara, Ferrara

[12] Department of General, Emergency and Trauma Surgery, Bufalini Hospital, Cesena

[13] Department of Health Science, University of Piemonte Orientale, Ospedale Maggiore della Carità, Novara

[14] Department of Pharmacy, Health and Nutritional Sciences, University of Calabria, Rende

[15] Department of Surgery, Madonna del Soccorso Hospital, San Benedetto del Tronto

[16] Alma Mater Studiorum, Università di Bologna, IRCCS Azienda Ospedaliero-Universitaria di Bologna, Bologna

[17] Department of Electric Engineering and Information Technologies, University of Naples Federico II, Naples

来源：

World Journal of Emergency Surgery | / 20卷 / 1期

关键词：

Acute Pancreatitis; Alcoholic; Biliary; Recurrence; Risk factors;

D O I：

10.1186/s13017-025-00601-x

中图分类号：

学科分类号：

摘要：

Purpose: Acute Pancreatitis (AP) is a prevalent clinical pancreatic disorder characterized by acute inflammation of the pancreas, frequently associated with biliary or alcoholic events. If not treated with cholecystectomy after the first episode, patients may experience a recurrence of AP, with consequent need for emergency surgery and increased risk of death. Analyzing the risk factors that may contribute to the recurrence of Biliary and Alcoholic Pancreatitis (BAP and AAP), future research can be driven toward new solutions for preventing and treating this pancreatic disease. Methods: A systematic review was conducted selecting studies from BiomedCentral, PubMed, Scopus and Web of Science by two independent reviewers. Publications were considered only if written in English in the time interval between January 2000 and June 2024 and investigated the risk factors for the recurrence of BAP and AAP. At the end of the selection, a quality assessment phase was conducted using the PROBAST tool. Results: In this systematic review, 8 articles were selected out of 6.945, involving a total sample of 11.271 patients of which 38.77% developed recurrence episodes. 37.5% of the included studies focus on recurrent acute biliary pancreatitis (RBAP), while 62.5% are dedicated to recurrent acute alcoholic pancreatitis (RAAP). The risk factors for the recurrence of AP showed a clear differentiation between the alcoholic and biliary etiology. Most of the considered studies adopted a retrospective design, characterized by a susceptibility to potential methodological biases. However, the trend indicated a more recent increase in prospective studies, together with a greater focus on identifying and understanding the possible risk factors associated with the recurrence of acute pancreatitis (RAP). This result highlighted the progress in the scientific approach toward a more rigorous and systematic assessment of the causes and dynamics that influence the recurrence of the disease. Conclusion: Studies highlighted the importance of lifestyle factors, clinical complications, and surgical interventions that can impact the risk of biliary or alcoholic recurrent acute pancreatitis. Increased and systematic adoption of artificial intelligence-based tools could significantly impact future knowledge relating to the risks of recurrence and relative possibilities of prevention. © The Author(s) 2025.

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