A systematic review of the predictive factors for the recurrence of acute pancreatitis

被引：0

作者：

Pacella, Daniela ^{[1
]}

De Simone, Adriano ^{[1
,17
]}

Pisanu, Adolfo ^{[2
]}

Pellino, Gianluca ^{[3
]}

Selvaggi, Lucio ^{[3
]}

Murzi, Valentina ^{[2
]}

Locci, Eleonora ^{[2
]}

Ciabatti, Giulia ^{[4
]}

Mastrangelo, Laura ^{[4
]}

Jovine, Elio ^{[4
]}

Rottoli, Matteo ^{[6
,16
]}

Calini, Giacomo ^{[6
]}

Cardelli, Stefano ^{[6
,16
]}

Catena, Fausto ^{[12
]}

Vallicelli, Carlo ^{[12
]}

Bova, Raffaele ^{[12
]}

Vigutto, Gabriele ^{[12
]}

D'Acapito, Fabrizio ^{[5
]}

Ercolani, Giorgio ^{[5
]}

Solaini, Leonardo ^{[5
]}

Biloslavo, Alan ^{[7
]}

Germani, Paola ^{[7
]}

Colutta, Camilla ^{[7
]}

Lepiane, Pasquale ^{[8
]}

Scaramuzzo, Rosa ^{[8
]}

Occhionorelli, Savino ^{[11
]}

Lacavalla, Domenico ^{[11
]}

Sibilla, Maria Grazia ^{[11
]}

Olmi, Stefano ^{[10
]}

Uccelli, Matteo ^{[10
]}

Oldani, Alberto ^{[10
]}

Giordano, Alessio ^{[9
]}

Guagni, Tommaso ^{[9
]}

Perini, Davina ^{[9
]}

Pata, Francesco ^{[14
]}

Nardo, Bruno ^{[14
]}

Paglione, Daniele ^{[14
]}

Franco, Giusi ^{[14
]}

Donadon, Matteo ^{[13
]}

Di Martino, Marcello ^{[13
]}

Di Saverio, Salomone ^{[15
]}

Cardinali, Luca ^{[15
]}

Travaglini, Grazia ^{[15
]}

Bruzzese, Dario ^{[1
]}

Podda, Mauro ^{[2
]}

机构：

[1] Univ Naples Federico II, Dept Publ Hlth, Naples, Italy

[2] Univ Cagliari, Dept Surg Sci, Emergency Surg Unit, Cagliari, Italy

[3] Univ Campania Luigi Vanvitelli, Dept Adv Med & Surg Sci, Naples, Italy

[4] Univ Bologna, Maggiore Hosp, Dept Med & Surg Sci, Bologna, Italy

[5] Univ Bologna, Morgagni Pierantoni Hosp Forli, Dept Med & Surg Sci, Forli, Italy

[6] Univ Bologna, St Orsola Hosp, Dept Med & Surg Sci, Bologna, Italy

[7] Univ Trieste, Dept Gen Surg, Azienda Sanit Universitaria Giuliano Isontina, Trieste, Italy

[8] San Paolo Hosp Civitavecchia, Dept Surg, Rome, Italy

[9] Careggi Hosp, Dept Emergency Surg, Florence, Italy

[10] San Donato Hosp Zingonia, Dept Gen Surg, Bergamo, Italy

[11] Univ Ferrara, Dept Morphol Surg & Expt Med, Ferrara, Italy

[12] Bufalini Hosp, Dept Gen Emergency & Trauma Surg, Cesena, Italy

[13] Univ Piemonte Orientale, Osped Maggiore Carita, Dept Hlth Sci, Novara, Italy

[14] Univ Calabria, Dept Pharm Hlth & Nutr Sci, Arcavacata Di Rende, Italy

[15] Madonna Soccorso Hosp, Dept Surg, San Benedetto Tronto, Italy

[16] Univ Bologna, Alma Mater Studiorum, IRCCS Azienda Osped Univ Bologna, Bologna, Italy

[17] Univ Naples Federico II, Dept Elect Engn & Informat Technol, Naples, Italy

来源：

WORLD JOURNAL OF EMERGENCY SURGERY | 2025年 / 20卷 / 01期

关键词：

Risk factors; Acute Pancreatitis; Recurrence; Biliary; Alcoholic; ACUTE BILIARY PANCREATITIS; ACUTE ALCOHOLIC PANCREATITIS; RISK-FACTORS; DELAYED CHOLECYSTECTOMY; GLOBAL INCIDENCE; 1ST EPISODE; ETIOLOGY; CLASSIFICATION; ASSOCIATION; MORTALITY;

D O I：

10.1186/s13017-025-00601-x

中图分类号：

R4 [临床医学];

学科分类号：

1002 ; 100602 ;

摘要：

PurposeAcute Pancreatitis (AP) is a prevalent clinical pancreatic disorder characterized by acute inflammation of the pancreas, frequently associated with biliary or alcoholic events. If not treated with cholecystectomy after the first episode, patients may experience a recurrence of AP, with consequent need for emergency surgery and increased risk of death. Analyzing the risk factors that may contribute to the recurrence of Biliary and Alcoholic Pancreatitis (BAP and AAP), future research can be driven toward new solutions for preventing and treating this pancreatic disease.MethodsA systematic review was conducted selecting studies from BiomedCentral, PubMed, Scopus and Web of Science by two independent reviewers. Publications were considered only if written in English in the time interval between January 2000 and June 2024 and investigated the risk factors for the recurrence of BAP and AAP. At the end of the selection, a quality assessment phase was conducted using the PROBAST tool.ResultsIn this systematic review, 8 articles were selected out of 6.945, involving a total sample of 11.271 patients of which 38.77% developed recurrence episodes. 37.5% of the included studies focus on recurrent acute biliary pancreatitis (RBAP), while 62.5% are dedicated to recurrent acute alcoholic pancreatitis (RAAP). The risk factors for the recurrence of AP showed a clear differentiation between the alcoholic and biliary etiology. Most of the considered studies adopted a retrospective design, characterized by a susceptibility to potential methodological biases. However, the trend indicated a more recent increase in prospective studies, together with a greater focus on identifying and understanding the possible risk factors associated with the recurrence of acute pancreatitis (RAP). This result highlighted the progress in the scientific approach toward a more rigorous and systematic assessment of the causes and dynamics that influence the recurrence of the disease.ConclusionStudies highlighted the importance of lifestyle factors, clinical complications, and surgical interventions that can impact the risk of biliary or alcoholic recurrent acute pancreatitis. Increased and systematic adoption of artificial intelligence-based tools could significantly impact future knowledge relating to the risks of recurrence and relative possibilities of prevention.

引用

页数：13

共 61 条

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