Metabolic Syndrome and Insulin Resistance in Romania

被引:0
作者
Stefan, Adela Gabriela [1 ]
Clenciu, Diana [2 ]
Mitrea, Adina [2 ]
Vladu, Ionela Mihaela [2 ]
Protasiewicz-Timofticiuc, Diana Cristina [3 ]
Rosu, Maria Magdalena [4 ]
Maria, Daniela Teodora [5 ]
Dinu, Ilie Robert [5 ]
Gheonea, Theodora Claudia [2 ]
Vladu, Beatrice Elena [6 ]
Efrem, Ion Cristian [7 ]
Mota, Eugen [8 ]
Mota, Maria [8 ]
机构
[1] Calafat Municipal Hosp, Dept Diabet Nutr & Metab Dis, Calafat 205200, Romania
[2] Univ Med & Pharm Craiova, Fac Med, Dept Diabet Nutr & Metab Dis, Craiova 200349, Romania
[3] Clin Cty Emergency Hosp Craiova, Dept Diabet Nutr & Metab Dis, Craiova 200642, Romania
[4] Univ Med & Pharm Craiova, Fac Midw & Nursing, Dept Diabet Nutr & Metab Dis, Craiova 200349, Romania
[5] Univ Med & Pharm Craiova, Fac Med, Dept Nephrol, Craiova 200349, Romania
[6] Univ Med & Pharm Craiova, Fac Med, Craiova 200349, Romania
[7] Univ Med & Pharm Craiova, Fac Dent, Dept Internal Med Med Semiol, Craiova 200349, Romania
[8] Univ Med & Pharm Craiova, Doctoral Sch, Craiova 200349, Romania
关键词
metabolic syndrome; insulin resistance; PREDATORR study; Romania; LIVER-DISEASE; GLUCOSE; TRIGLYCERIDE; POPULATION; PREVALENCE; DENSITY; OBESITY; INDEX; HOMA;
D O I
10.3390/ijms26062389
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Metabolic syndrome (MetS) represents a huge burden on the health system. This study aimed to investigate the association between MetS and certain indirect insulin resistance (IR) indicators according to gender. The triglyceride-glucose index (TyG), TyG-body mass index (TyG-BMI), the TyG-waist-to-height ratio (TyG-WHtR), TyG-waist circumference (TyG-WC), the triglyceride to high-density-lipoprotein cholesterol index (TG/HDL-c) and recently proposed indicators such as the metabolic score for IR (MetS-IR), TyG-neck circumference (TyG-NC) and the TyG-neck-circumference-to-height ratio (TyG-NHtR) were evaluated in 2594 subjects enrolled in the PREDATORR study. Univariate and multivariate logistic regression was performed to identify the association between MetS and the indirect IR indicators, as well as the risk factors. The participants were divided into two groups, according to gender. Data were analyzed using SPSS version 26.0. TyG, TyG-WC, TyG-NC, TyG-NHtR and TG/HDL-c had higher values in the male group, while TyG-BMI, TyG-WHtR and MetS-IR had approximately equal values in the two studied groups, but also statistically significantly higher values in MetS (+) vs. MetS (-) subjects (p < 0.001). For both studied groups, the multivariate logistic regression analysis demonstrated that TyG and MetS-IR were independent predictors for MetS. Both in the female and in the male group, TyG had the largest area under the receiver operating characteristic (AUROC) curve. Thus, in females, the TyG AUROC curve was 0.890; 95% CI 0.873-0.907; p < 0.001; cut-off value 8.51, with 81.4% sensitivity and 80.0% specificity. In males, the TyG AUROC curve was 0.880; 95% CI 0.861-0.899; p < 0.001; cut-off value 8.69, with 78.5% sensitivity and 84.6% specificity. All of the analyzed indirect IR indicators had statistically significantly higher values in MetS (+) vs. MetS (-) subjects. TyG and MetS-IR are independent predictive factors for MetS, regardless of the subject's gender.
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页数:16
相关论文
共 51 条
[21]   METS-IR, a novel simple insulin resistance indexes, is associated with hypertension in normal-weight Chinese adults [J].
Liu, Xing Zhen ;
Fan, Jie ;
Pan, Shu Jun .
JOURNAL OF CLINICAL HYPERTENSION, 2019, 21 (08) :1075-1081
[22]   A novel index for diagnosis of type 2 diabetes mellitus: Cholesterol, High density lipoprotein, and Glucose (CHG) index [J].
Mansoori, Amin ;
Nosrati, Mina ;
Dorchin, Mohsen ;
Mohammadyari, Fatemeh ;
Derakhshan-Nezhad, Elahe ;
Ferns, Gordon ;
Esmaily, Habibollah ;
Ghayour-Mobarhan, Majid .
JOURNAL OF DIABETES INVESTIGATION, 2024, :309-314
[23]   Impact of metabolic syndrome and metabolic dysfunction-associated fatty liver disease on cardiovascular risk by the presence or absence of type 2 diabetes and according to sex [J].
Matsubayashi, Yasuhiro ;
Fujihara, Kazuya ;
Yamada-Harada, Mayuko ;
Mitsuma, Yurie ;
Sato, Takaaki ;
Yaguchi, Yuta ;
Osawa, Taeko ;
Yamamoto, Masahiko ;
Kitazawa, Masaru ;
Yamada, Takaho ;
Kodama, Satoru ;
Sone, Hirohito .
CARDIOVASCULAR DIABETOLOGY, 2022, 21 (01)
[24]   HOMEOSTASIS MODEL ASSESSMENT - INSULIN RESISTANCE AND BETA-CELL FUNCTION FROM FASTING PLASMA-GLUCOSE AND INSULIN CONCENTRATIONS IN MAN [J].
MATTHEWS, DR ;
HOSKER, JP ;
RUDENSKI, AS ;
NAYLOR, BA ;
TREACHER, DF ;
TURNER, RC .
DIABETOLOGIA, 1985, 28 (07) :412-419
[25]   Newly proposed insulin resistance indexes called TyG-NC and TyG-NHtR show efficacy in diagnosing the metabolic syndrome [J].
Mirr, M. ;
Skrypnik, D. ;
Bogdanski, P. ;
Owecki, M. .
JOURNAL OF ENDOCRINOLOGICAL INVESTIGATION, 2021, 44 (12) :2831-2843
[26]   Prevalence of diabetes mellitus and prediabetes in the adult Romanian population: PREDATORR study [J].
Mota, Maria ;
Popa, Simona Georgiana ;
Mota, Eugen ;
Mitrea, Adina ;
Catrinoiu, Doina ;
Cheta, Dan Mircea ;
Guja, Cristian ;
Hancu, Nicolae ;
Ionescu-Tirgoviste, Constantin ;
Lichiardopol, Radu ;
Mihai, Bogdan Mircea ;
Popa, Amorin Remus ;
Zetu, Cornelia ;
Bala, Cornelia Gabriela ;
Roman, Gabriela ;
Serafinceanu, Cristian ;
Serban, Viorel ;
Timar, Romulus ;
Veresiu, Ioan Andrei ;
Vlad, Adrian Radu .
JOURNAL OF DIABETES, 2016, 8 (03) :336-344
[27]   The accuracy of triglyceride-glucose (TyG) index for the screening of metabolic syndrome in adults: A systematic review and meta-analysis [J].
Nabipoorashra, Seyed Ali ;
Seyedi, Seyed Arsalan ;
Rabizadeh, Soghra ;
Ebrahimi, Menooa ;
Ranjbar, Shadi Amin ;
Reyhan, Sahar Karimpour ;
Meysamie, Alipasha ;
Nakhjavani, Manouchehr ;
Esteghamati, Alireza .
NUTRITION METABOLISM AND CARDIOVASCULAR DISEASES, 2022, 32 (12) :2677-2688
[28]  
Nolan Paul B, 2017, Prev Med Rep, V7, P211, DOI 10.1016/j.pmedr.2017.07.004
[29]   Global, regional, and country estimates of metabolic syndrome burden in children and adolescents in 2020: a systematic review and modelling analysis [J].
Noubiap, Jean Jacques ;
Nansseu, Jobert Richie ;
Lontchi-Yimagou, Eric ;
Nkeck, Jan Rene ;
Nyaga, Ulrich Flore ;
Ngouo, Anderson T. ;
Tounouga, Dahlia Noelle ;
Tianyi, Franck Leonel ;
Foka, Audrey Joyce ;
Ndoadoumgue, Aude Laetitia ;
Bigna, Jean Joel .
LANCET CHILD & ADOLESCENT HEALTH, 2022, 6 (03) :158-170
[30]   Metabolic syndrome: a closer look at the growing epidemic and its associated pathologies [J].
O'Neill, S. ;
O'Driscoll, L. .
OBESITY REVIEWS, 2015, 16 (01) :1-12