Clinical subtypes of psoriasis and their associated comorbidities in a Mexican population

Background: Psoriasis is an inflammatory, systemic, and chronic disease affecting 2.9% of Mexicans, It is associated with metabolic and inflammatory comorbidities. Objective: To determine the distribution of psoriasis subtypes and associated comorbidities in a tertiary hospital in Mexico City. Material and methods: Descriptive, observational, retrospective, and crosssectional study conducted on patients with psoriasis (1999-2023). Data collected included age, sex, subtype, year of diagnosis and death, disease progression, severity index (PASI), and comorbidities. Qualitative variables were described in frequencies and percentages; quantitative variables with mean and standard deviation. Logistic regression was performed to evaluate associations. Results: The study included 221 patients (116 men) with an average age of 55 years. Plaque psoriasis was the most frequent subtype (85%), and the main comorbidities were dyslipidemia (33%) and hypertension (33%). Men showed a higher proportion of plaque psoriasis (97% versus 75%), while women had more palmoplantar psoriasis (9.5% versus 0.9%). Conclusions: The association with metabolic and cardiovascular comorbidities highlights the need for multidisciplinary management and early detection. This study underscores the importance of researching psoriasis in Mexico to improve prevention and treatment and guide public health policies.