Combined antifungal therapy with immunostimulation for refractory cutaneous and peritoneal mucormycosis caused by Rhizopus microsporus

被引：1

作者：

Mhenni, Rania ^{[1
,2
]}

Delliere, Sarah ^{[3
,4
]}

Ben Maaouia, Chiheb ^{[1
,2
]}

Hamane, Samia ^{[4
]}

Deniau, Benjamin ^{[1
,2
,3
,5
,6
,7
]}

Mahevas, Thibault ^{[8
]}

Chaussard, Maite ^{[1
,2
]}

Coutrot, Maxime ^{[1
,2
]}

Guillemet, Lucie ^{[1
,2
]}

Cupaciu, Alexandru ^{[1
,2
]}

Pharaboz, Alexandre ^{[1
,2
]}

Walter, Thais ^{[1
,2
,3
]}

Boutin, Louis ^{[1
,2
,3
,5
]}

Benyamina, Mourad ^{[1
,2
]}

Corte, Helene ^{[9
]}

Delale, Charles ^{[10
]}

Chaouat, Marc ^{[3
,11
]}

Guihot, Amelie

Lanternier, Fanny ^{[3
,12
]}

Alanio, Alexandre ^{[3
,4
]}

Depret, Francois ^{[1
,2
,3
,5
,6
,7
]}

Serris, Alexandra ^{[3
,12
]}

Dudoignon, Emmanuel ^{[1
,2
,3
,5
,6
,7
]}

机构：

[1] Grp Hosp St Louis Lariboisiere, AP HP, Dept Anesthesiol, 1 Ave Claude Vellefaux, F-75010 Paris, France

[2] Crit Care & Burn Unit, 1 Ave Claude Vellefaux, F-75010 Paris, France

[3] Univ Paris Cite, Paris, France

[4] Dept Mycol & Parasitol, Paris, France

[5] Grp Hosp St Louis Lariboisiere, Lariboisiere Hosp, AP HP, France Inst Natl Sante & Rech Med INSERM,INSERM UM, Paris, France

[6] INI CRCT Network, Nancy, France

[7] FHU PROMICE, Paris, France

[8] St Louis Hosp, Dept Dermatol, St Louis, France

[9] St Louis Hosp, AP HP, Abdominal Surg, St Louis, France

[10] CH Blois, Intens Care Unit, Blois, France

[11] St Louis Hosp, AP HP, Plast Surg, St Louis, France

[12] Hop Necker Enfants Malad, Dept Infect Dis, Paris, France

来源：

DIAGNOSTIC MICROBIOLOGY AND INFECTIOUS DISEASE | 2025年 / 111卷 / 03期

关键词：

Immunostimulation; Immunotherapy; Mucormycosis; Rhizopus microsporus; NIVOLUMAB;

D O I：

10.1016/j.diagmicrobio.2024.116653

中图分类号：

R51 [传染病];

学科分类号：

100401 ;

摘要：

Mucormycosis is a fungal infection typically affecting immunocompromised patients. Here, we report a severe case of invasive cutaneous and peritoneal mucormycosis caused by Rhizopus microsporus, successfully treated with a combination of antifungal therapy, PD-1 inhibitor, and interferon-gamma. We highlight the importance of personalized immunotherapy in refractory cases of invasive mucormycosis.

引用

页数：5

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