Prevalence and factors associated with dementia in Lesotho: A cross-sectional, population-based study

被引：0

作者：

Johnson, Natalie E. ^{[1
,2
]}

Belus, Jennifer M. ^{[1
,2
]}

Gerber, Felix ^{[1
,2
]}

Lee, Tristan T. ^{[1
,2
]}

Ayakaka, Irene ^{[2
,3
]}

Letsoela, Pearl ^{[4
]}

Molulela, Manthabiseng ^{[3
]}

Chammartin, Frederique ^{[1
,2
]}

Amstutz, Alain ^{[1
,2
,5
,6
]}

Labhardt, Niklaus D. ^{[1
,2
]}

机构：

[1] Univ Hosp, Dept Clin Res, Div Clin Epidemiol, Basel, Switzerland

[2] Univ Basel, Basel, Switzerland

[3] SolidarMed, Partnerships Hlth, Happy Villa, Maseru, Lesotho

[4] Minist Hlth Lesotho, Maseru, Lesotho

[5] Oslo Univ Hosp, Oslo Ctr Biostat & Epidemiol, Oslo, Norway

[6] Univ Bristol, Bristol Med Sch, Populat Hlth Sci, Bristol, England

来源：

ALZHEIMERS & DEMENTIA | 2025年 / 21卷 / 02期

基金：

瑞士国家科学基金会;

关键词：

body mass index; dementia; Lesotho; lifestyle; physical activity; VALIDATION; QUESTIONNAIRE; PHQ-9;

D O I：

10.1002/alz.14614

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

INTRODUCTION: Limited research has examined dementia prevalence and associated factors in Lesotho. This study investigates dementia prevalence and the associated factors in Lesotho. METHODS: A survey in Lesotho included 1738 participants screened for dementia and potential associated factors with a focus on modifiable factors. Associations were evaluated using logistic regression models. RESULTS: The median age was 66 years, with 54.83% women. The prevalence of dementia was 4.89%. Those with depressive symptoms (adjusted odds ratio [aOR]: 3.97, 95% confidence interval [CI]: 1.39-11.30), age >= 75 (aOR: 2.68, 95% CI: 1.42-5.04), and underweight (aOR 2.30, 95% CI: 1.23-4.29) had increased odds of dementia. Those with moderate (aOR: 0.32, 95% CI: 0.17-0.58) to high (aOR: 0.35, 95% CI: 0.16-0.77) physical activity and obesity (aOR: 0.30, 95% CI: 0.11-0.80) presented lower odds for dementia. DISCUSSION: This study provides a contemporary estimate of dementia prevalence in Lesotho, highlighting an association with modifiable factors.

引用

页数：10

共 44 条

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