Sex Steroids and Brain-Derived Neurotrophic Factor Interactions in the Nervous System: A Comprehensive Review of Scientific Data

被引：0
作者：
de Assis, Gilmara Gomes [1 ,2 ]
de Sousa, Maria Bernardete Cordeiro [3 ]
Murawska-Cialowicz, Eugenia [4 ]
机构：
[1] Inst Politecn Viana Castelo, Escola Super Desporto & Lazer, Rua Escola Ind & Comercial NunAlvares, P-4900347 Viana Do Castelo, Portugal
[2] Sport Phys Act & Hlth Res & Innovat Ctr, P-4900347 Viana do Castelo, Portugal
[3] Univ Fed Rio Grande do Norte, Brain Inst, BR-59078970 Natal, RN, Brazil
[4] Wroclaw Univ Hlth & Sport Sci, Dept Physiol & Biomech, PL-51612 Wroclaw, Poland
来源：
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES | 2025年 / 26卷 / 06期
关键词：
estrogen; estradiol; testosterone; progesterone; brain-derived neurotrophic factor; nervous system; FACTOR MESSENGER-RNA; DENDRITIC SPINE FORMATION; ESTROGEN-RECEPTORS ALPHA; BDNF GENE-EXPRESSION; TYROSINE KINASE-B; AGED FEMALE; PROGESTERONE INCREASES; HYPOTHALAMIC NEURONS; SYNAPTIC PLASTICITY; ESTRADIOL TREATMENT;
D O I：
10.3390/ijms26062532
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Sex steroids and the neurotrophin brain-derived neurotrophic factor (BDNF) participate in neural tissue formation, phenotypic differentiation, and neuroplasticity. These processes are essential for the health and maintenance of the central nervous system. Aim: The aim of our review is to elucidate the interaction mechanisms between BDNF and sex steroids in neuronal function. Method: A series of searches were performed using Mesh terms for androgen/receptors, estrogen/receptors, and BDNF/receptors, and a collection of the scientific data available on PubMed up to February 2025 about mechanical interactions between BDNF and sex steroids was included in this literature review. Discussion: This review discussed the influence of sex steroids on the formation and/or maintenance of neural circuits via different mechanisms, including the regulation of BDNF expression and signaling. Estrogens exert a time- and region-specific effect on BDNF synthesis. The nuclear estrogen receptor can directly regulate BDNF expression, independently of the presence of estrogen, in neuronal cells, whereas progesterone and testosterone upregulate BDNF expression via their specific nuclear receptors. In addition, testosterone has a positive effect on BDNF release by glial cells, which lack androgen receptors.
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页数：35
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