mRNA Vaccination: An Outlook on Innate Sensing and Adaptive Immune Responses

被引：2

作者：

Doost, Janan Shoja ^{[1
]}

Fazel, Fatemeh ^{[1
]}

Boodhoo, Nitish ^{[1
]}

Sharif, Shayan ^{[1
]}

机构：

[1] Univ Guelph, Ontario Vet Coll, Dept Pathobiol, Guelph, ON N1G 2W1, Canada

来源：

VIRUSES-BASEL | 2024年 / 16卷 / 09期

基金：

加拿大自然科学与工程研究理事会;

关键词：

mRNA vaccine; innate sensing; adaptive responses; adjuvanticity; CYTOTOXIC T-LYMPHOCYTES; SINGLE-STRANDED RNA; IN-VIVO; CO-DELIVERY; RIG-I; RECOGNITION; RECEPTOR; TRANSLATION; ACTIVATION; INDUCTION;

D O I：

10.3390/v16091404

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Vaccination has led to significant dismantling of infectious diseases worldwide. Since the dawn of the SARS-CoV-2 pandemic, there has been increased popularity in the usage and study of the mRNA vaccine platform. Here, we highlight fundamental knowledge on mRNA vaccine pharmacology, followed by the immunity conferred by innate sensing and adaptive responses resulting from exposure to the mRNA vaccine construct and encapsulation materials. A better understanding of these immune mechanisms will shed light on further improvements in mRNA vaccine design, aiming to improve efficiency and optimize immune responses upon inoculation.

引用

页数：14

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