The effects of zinc supplementation on body fat mass in hemodialysis patients: An open-label randomized controlled trial

被引：0
|
作者：
Fukasawa, Hirotaka [1 ]
Yamawaki, Mito [1 ]
Furuya, Jun [1 ]
Omata, Kyosuke [1 ]
Kaneko, Mai [1 ]
Matsuyama, Takashi [1 ]
Yasuda, Hideo [2 ]
Furuya, Ryuichi [1 ]
机构：
[1] Iwata City Hosp, Dept Internal Med, Renal Div, 512-3 Ohkubo, Iwata, Shizuoka 4388550, Japan
[2] Hamamatsu Univ Sch Med, Dept Med 1, Hamamatsu, Shizuoka, Japan
来源：
THERAPEUTIC APHERESIS AND DIALYSIS | 2024年
关键词：
fat mass; hemodialysis; nonfat mass; zinc deficiency; MORTALITY; INDEX; PREDICTORS; SURVIVAL;
D O I：
10.1111/1744-9987.14218
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Introduction: Zinc deficiency is highly prevalent in HD patients. On the other hand, it remains unknown about the role of zinc in their nutritional status. Methods: We conducted an open-label randomized controlled trial. We investigated (i) the relationship between serum zinc levels and body composition and (ii) the effects of zinc supplementation on the composition of 48 HD patients with zinc deficiency. Results: Serum zinc levels were significantly correlated with body fat weight (p < 0.01), but not with nonfat tissue weight. Multiple regression analyses demonstrated that serum zinc levels were a significant independent predictor of body fat weight (p < 0.001). Furthermore, the weight of body fat significantly increased in the group that received 1-year zinc supplementation (p < 0.05), but not in the group that did not. Conclusion: Our findings indicate that zinc deficiency plays an important role in fat metabolism in HD patients with its deficiency.
引用
收藏
页码：170 / 177
页数：8
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