Research progress in OX40/OX40L in allergic diseases

被引：1

作者：

Song, Rongrong ^{[1
]}

Zhang, Huanlei ^{[1
]}

Liang, Zhuoping ^{[1
]}

机构：

[1] Southwest Med Univ, Affiliated Hosp, Dept Otolaryngol Head & Neck Surg, 25 Taiping St, Luzhou 646000, Sichuan, Peoples R China

来源：

INTERNATIONAL FORUM OF ALLERGY & RHINOLOGY | 2024年 / 14卷 / 12期

关键词：

allergic rhinitis; asthma; atopic dermatitis; OX40; OX40L; ATOPIC-DERMATITIS; RHINITIS; QUESTIONS; BLOCKADE;

D O I：

10.1002/alr.23469

中图分类号：

R76 [耳鼻咽喉科学];

学科分类号：

100213 ;

摘要：

OX40/OX40L are costimulatory molecules in the tumor necrosis factor superfamily. Numerous studies have shown that OX40/OX40L are involved in immune regulation, especially in the proliferation and differentiation of T cells and the generation of memory T cells, which play important roles in allergic diseases. In recent years, the use of OX40/OX40L as therapeutic targets for treating T-cell-mediated diseases has attracted the interest of scholars. This paper reviews the role of OX40/OX40L in allergic diseases and the progress in clinical treatments targeting this signaling pathway.

引用

页码：1921 / 1928

页数：8

共 63 条

[1]

Abbafati C, 2020, LANCET, V396, P1204

[2] Epigenetic control of inflammation in Atopic Dermatitis [J].

Akhtar, Sabah ;

Alsayed, Reem Khaled M. E. ;

Ahmad, Fareed ;

Alhammadi, Ayda ;

Al-Khawaga, Sara ;

Alharami, Sara Mohamed A. M. ;

Alam, Majid Ali ;

Al Naama, Khalifa Abdulla H. N. ;

Buddenkotte, Joerg ;

Uddin, Shahab ;

Steinhoff, Martin ;

Ahmad, Aamir .

SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY, 2024, 154 :199-207

[3] OX40 blockade inhibits house dust mite driven allergic lung inflammation in mice and in vitro allergic responses in humans [J].

Burrows, Katie E. ;

Dumont, Celine ;

Thompson, Clare L. ;

Catley, Matthew C. ;

Dixon, Kate L. ;

Marshall, Diane .

EUROPEAN JOURNAL OF IMMUNOLOGY, 2015, 45 (04) :1116-1128

[4] Global Asthma Report 2022: a wake-up call to enhance care and treatment for asthma globally [J].

Chakaya, J. ;

Ait-Khaled, N. .

INTERNATIONAL JOURNAL OF TUBERCULOSIS AND LUNG DISEASE, 2022, 26 (11) :999-1000

[5]

Chaudhary Fihr, 2024, Arch Intern Med Res, V7, P114, DOI 10.26502/aimr.0170

[6] The TNF family in T cell differentiation and function - Unanswered questions and future directions [J].

Croft, Michael .

SEMINARS IN IMMUNOLOGY, 2014, 26 (03) :183-190

[7] Amygdalin Improves Allergic Asthma via the Thymic Stromal Lymphopoietin-dendritic Cell-OX40 Ligand Axis in a Mouse Model [J].

Cui, Wen ;

Zhou, Huan ;

Liu, Ya-zun ;

Yang, Yan ;

Hu, Yi-zhong ;

Han, Zhao-peng ;

Yu, Jian-er ;

Xue, Zheng .

IRANIAN JOURNAL OF ALLERGY ASTHMA AND IMMUNOLOGY, 2023, 22 (05) :430-439

[8] Allergology in Europe, the blueprint [J].

de Monchy, J. G. ;

Demoly, P. ;

Akdis, C. A. ;

Cardona, V. ;

Papadopoulos, N. G. ;

Schmid-Grendelmeier, P. ;

Gayraud, J. .

ALLERGY, 2013, 68 (10) :1211-1218

[9] Short ragweed pollen promotes M2 macrophage polarization via TSLP/TSLPR/OX40L signaling in allergic inflammation [J].

Deng, Ruzhi ;

Chen, Xin ;

Zhang, Yun ;

Bian, Fang ;

Gao, Ning ;

Hu, Jiaoyue ;

Wang, Changjun ;

de Souza, Rodrigo G. ;

Lu, Fan ;

Pflugfelder, Stephen C. ;

Li, De-Quan .

MUCOSAL IMMUNOLOGY, 2019, 12 (05) :1141-1149

[10] The OX40 Axis is Associated with Both Systemic and Local Involvement in Atopic Dermatitis [J].

Elsner, Julie Sophie Hohwu ;

Carlsson, Michael ;

Stougaard, Julie Kristine ;

Nygaard, Uffe ;

Buchner, Matthias ;

Foelster-Holst, Regina ;

Hvid, Malene ;

Vestergaard, Christian ;

Deleuran, Mette ;

Deleuran, Bent .

ACTA DERMATO-VENEREOLOGICA, 2020, 100 (03) :1-5

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