Distinctive CD8+T cell activation by antigen-presenting plasmacytoid dendritic cells compared to conventional dendritic cells

被引：0

作者：

van der Sluis, Renee M. ^{[1
,2
]}

Garcia-Rodriguez, Juan L. ^{[2
]}

Nielsen, Ian Helstrup ^{[2
]}

Gris-Oliver, Albert ^{[2
]}

Becker, Jennifer ^{[3
,4
]}

Costa, Bibiana ^{[3
,4
]}

Chaudhry, M. Zeeshan ^{[4
,5
,6
]}

Werner, Marvin ^{[2
]}

Laustsen, Anders ^{[2
]}

Pedersen, Jesper G. ^{[1
]}

Gammelgaard, Kristine R. ^{[1
]}

Mogensen, Trine H. ^{[2
,7
]}

Kalinke, Ulrich ^{[3
,4
,8
]}

Cicin-Sain, Luka ^{[4
,5
,6
]}

Bak, Rasmus O. ^{[1
,2
]}

Kristensen, Lasse S. ^{[2
]}

Jakobsen, Martin R. ^{[2
]}

机构：

[1] Aarhus Univ, Aarhus Inst Adv Studies, DK-8000 Aarhus, Denmark

[2] Aarhus Univ, Dept Biomed, DK-8000 Aarhus, Denmark

[3] Helmholtz Ctr Infect Res, Inst Expt Infect Res, Ctr Expt & Clin Infect Res, TWINCORE, Hannover, Germany

[4] Hannover Med Sch, Hannover, Germany

[5] Helmholtz Ctr Infect Res, Dept Viral Immunol, Hannover Braunschweig Site, D-38124 Braunschweig, Germany

[6] Helmholtz Ctr Infect Res, Ctr Individualized Infect Med, Hannover, Germany

[7] Aarhus Univ Hosp, Dept Infect Dis, Aarhus, Denmark

[8] Hannover Med Sch, Cluster Excellence Resolving Infect Susceptibil, RESIST, EXC 2155, Hannover, Germany

来源：

CELL REPORTS | 2025年 / 44卷 / 03期

关键词：

CD8(+) T-CELLS; CROSS-PRESENTATION; INTERFERON-ALPHA; IN-VITRO; VIRUS; GENERATION; RESPONSES; CD4(+); DIFFERENTIATION; SPECIALIZATION;

D O I：

10.1016/j.celrep.2025.115413

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Plasmacytoid dendritic cells (pDCs) play a pivotal role in immune responses, particularly against viral infections. pDCs exhibit diverse functions, including interferon production, cytokine secretion, and antigen presentation. Here, we investigate the antigen cross-presentation capacity of pDCs and their role in CD8+ T cell activation. Utilizing a culturing system with CD8+ T cells and autologous pDCs derived from circulating CD34+ hematopoietic stem and progenitor cells, we demonstrate that pDCs efficiently activate CD8+ T cells via cross-presentation, promoting T cell expansion and cytotoxic activity. The antigen presentation capacity of pDCs is comparable to that of monocyte-derived dendritic cells (moDCs) and myeloid dendritic cells, which are known for their efficient antigen-presentation capacity. Transcriptomic analysis reveals genetic signatures in CD8+ T cells activated by pDCs distinct from moDCs, suggesting different activation mechanisms. These findings underscore the importance of pDCs in antigen presentation and their contribution to CD8+ T cell activation.

引用

页数：26

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