Case report: Long remission and survival following immunotherapy in a case of pulmonary pleomorphic carcinoma

被引:0
作者
Wang, Tongshan [1 ]
Chen, Muyang [2 ]
Wang, Anpeng [3 ]
Zhang, Hao [3 ]
机构
[1] Nanjing Med Univ, Nanjing Hosp 1, Cent Lab, Nanjing, Peoples R China
[2] Nanjing Med Univ, Sch Pediat, Nanjing, Jiangsu, Peoples R China
[3] Nanjing Med Univ, Affiliated Hosp 1, Dept Oncol, Nanjing, Jiangsu, Peoples R China
来源
FRONTIERS IN IMMUNOLOGY | 2024年 / 15卷
关键词
pleomorphic lung carcinoma; immunotherapy; camrelizumab; apatinib; long remission; LUNG-CANCER;
D O I
10.3389/fimmu.2024.1464900
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
In 2020, we reported on a case involving a 68-year-old male patient with a rare instance of pulmonary pleomorphic carcinoma exhibiting high PD-L1 expression. The patient experienced significant therapeutic success with the use of pembrolizumab, achieving partial tumor remission. Following the publication of that report, the patient continued on pembrolizumab at a dose of 200 mg/dl for 27 cycles, subsequently transitioning to a combination of pembrolizumab and bevacizumab for eight cycles. Due to elevated blood pressure, the regimen was adjusted back to monotherapy with pembrolizumab. As of July 9, 2024, the patient remains alive with a satisfactory quality of life. This follow-up report, coupled with a review of the literature from 2021 to 2024 on pulmonary pleomorphic carcinoma and its immunotherapeutic approaches, aims to present new insights and innovative strategies for treating this rare form of cancer.
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页数:5
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