The mechanisms of protective effect of a peptide from Pinctada martensii meat against alcohol-induced liver injury in mice

被引：0
作者：
Chen, Yifan [1 ,2 ]
Zhou, Jie [2 ]
Liu, Xiaoyang [1 ,3 ]
You, Lijun [1 ,2 ]
机构：
[1] State Key Lab Marine Food Proc & Safety Control, Qingdao 266400, Peoples R China
[2] South China Univ Technol, Sch Food Sci & Engn, 381 Wushan Rd, Guangzhou 510640, Peoples R China
[3] Dalian Polytech Univ, Sch Food Sci & Technol, Dalian 116034, Peoples R China
来源：
JOURNAL OF FUNCTIONAL FOODS | 2024年 / 122卷
关键词：
Pinctada martensii meat; Bioactive peptides; Alcohol liver injury; Gut microbiota; Metabolism; ANTIOXIDANT ACTIVITY; GUT MICROBIOTA; OXIDATIVE STRESS; EXPRESSION; APOPTOSIS; DISEASE;
D O I：
10.1016/j.jff.2024.106481
中图分类号：
TS2 [食品工业];
学科分类号：
0832 ;
摘要：
Alcoholic liver disease is one of the main causes of global liver disease-related deaths, which has emerged as a major health concern for people. In this study, a peptide was prepared from Pinctada Martensii meat (named HPM-3), and its protective effect against alcohol-induced liver damage in mice was investigated. The results indicated that intervention of HPM-3 significantly decreased the levels of transaminase and lactate dehydrogenase in serum, and improved the antioxidant enzyme activities in the liver. Besides, HPM-3 could alleviate alcohol-induced liver injury by mediating Keap1/Nrf2 signaling pathway. Moreover, HPM-3 could preserve the diversity of the gut microbiota, and restore the relative abundance of some microbial communities that were impacted by alcohol intervention. HPM-3 intervention also affected the secretion of L-glutamine and other associated metabolites and mediated the related metabolic pathways. The results would help to clarify the mechanisms of protective effects of marine peptides against alcohol-induced liver injury.
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页数：13
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