Therapeutic Potential of lncRNAs in Regulating Disulfidptosis for Cancer Treatment

被引：0

作者：

Abida ^{[1
]}

Altamimi, Abdulmalik S. A. ^{[2
]}

Ghaboura, Nehmat ^{[3
]}

Balaraman, Ashok Kumar ^{[4
]}

Rajput, Pranchal ^{[5
]}

Bansal, Pooja ^{[6
]}

Rawat, Sushama ^{[7
]}

Alanazi, Fadiyah Jadid ^{[8
,9
]}

Alruwaili, Abeer Nuwayfi ^{[10
]}

Aldhafeeri, Nouf Afit ^{[11
,12
]}

Ali, Haider ^{[13
,14
]}

Deb, Pran Kishore ^{[15
]}

机构：

[1] Northern Border Univ, Coll Pharm, Dept Pharmaceut Chem, Rafha 91911, Saudi Arabia

[2] Prince Sattam Bin Abdulaziz Univ, Coll Pharm, Dept Pharmaceut Chem, Al Kharj 11942, Saudi Arabia

[3] Batterjee Med Coll, Dept Pharm Practice, Pharm Program, POB 6231, Jeddah 21442, Saudi Arabia

[4] Univ Cyberjaya, Res & Enterprise, Cyber 11, Cyberjaya 63000, Selangor, Malaysia

[5] Chandigarh Grp Coll Jhanjeri, Chandigarh Pharm Coll, Mohali 140307, Punjab, India

[6] Vivekananda Global Univ, Dept Allied Healthcare & Sci, Jaipur 303012, Rajasthan, India

[7] Graph Era Deemed Univ, Dept Biotechnol, Bell Rd clement town, Dehra Dun, Uttarakhand, India

[8] Northern Border Univ, Coll Nursing, Publ Hlth Nursing Dept, Ar Ar, Saudi Arabia

[9] Northern Border Univ, Ctr Hlth Res, Ar Ar, Saudi Arabia

[10] Jouf Univ, Coll Nursing, Dept Nursing Adm & Educ, Al Jouf 72388, Saudi Arabia

[11] King Saud bin Abdulaziz Univ Hlth Sci, Coll Nursing, Riyadh, Saudi Arabia

[12] King Abdullah Int Med Res Ctr, Riyadh, Saudi Arabia

[13] Saveetha Univ, Saveetha Inst Med & Tech Sci, Saveetha Med Coll, Ctr Global Hlth Res, Chennai, India

[14] Dept Hosp Surg, IK Akhunbaev Kyrgyz State Med Acad, Bishkek, Kyrgyzstan

[15] Birla Inst Technol BIT, Dept Pharmaceut Sci & Technol, Ranchi 835215, Jharkhand, India

来源：

PATHOLOGY RESEARCH AND PRACTICE | 2024年 / 263卷

关键词：

Long non-coding RNA; Disulfidptosis; Cancer; Cell death; LONG NONCODING RNAS; COLON-CANCER; BREAST-CANCER; LUNG-CANCER; HEPATOCELLULAR-CARCINOMA; IMMUNOTHERAPY RESPONSES; COMPREHENSIVE ANALYSIS; PREDICTING PROGNOSIS; GASTRIC-CANCER; CELL;

D O I：

10.1016/j.prp.2024.155657

中图分类号：

R36 [病理学];

学科分类号：

100104 ;

摘要：

Non-coding RNAs (lncRNAs) play critical roles in various cellular processes, including a novel form of regulated cell death known as disulfidptosis, characterized by accumulating protein disulfide bonds and severe endoplasmic reticulum stress. This review highlights the therapeutic potential of lncRNAs in regulating disulfidptosis for cancer treatment, emphasizing their influence on key pathway components such as GPX4, SLC7A11, and PDIA family members. Recent studies have demonstrated that targeting specific lncRNAs can sensitize cancer cells to disulfidptosis, offering a promising approach to cancer therapy. The regulation of disulfidptosis by lncRNAs involves various signaling pathways, including oxidative stress, ER stress, and calcium signaling. This review also discusses the molecular mechanisms underlying lncRNA regulation of disulfidptosis, the challenges of developing lncRNA-based therapies, and the future potential of this rapidly advancing field in cancer research.

引用

页数：12

共 50 条

[31] From carcinogenesis to therapeutic avenues: lncRNAs and mTOR crosstalk in lung cancer [J].

Hussain, Md Sadique ;

Altamimi, Abdulmalik S. A. ;

Afzal, Muhammad ;

Almalki, Waleed Hassan ;

Kazmi, Imran ;

Alzarea, Sami I. ;

Saleem, Shakir ;

Prasher, Parteek ;

Oliver, Brian ;

Singh, Sachin Kumar ;

Macloughlin, Ronan ;

Dua, Kamal ;

Gupta, Gaurav .

PATHOLOGY RESEARCH AND PRACTICE, 2024, 253

[32] Unravelling the complexity of lncRNAs in autophagy to improve potential cancer therapy [J].

Wang, Yi ;

Fu, Yuqi ;

Lu, Yingying ;

Chen, Siwei ;

Zhang, Jin ;

Liu, Bo ;

Yuan, Yong .

BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER, 2023, 1878 (05)

[33] Development of a disulfidptosis-related prognostic model for endometrial cancer with potential therapeutic target [J].

Li, Chunmei ;

Fan, Xuefei ;

Wang, Xue ;

Yao, Yulan ;

Huang, Bing ;

Chen, Linlin ;

Cao, Lu ;

Peng, Tao ;

Lin, Yingying ;

Cai, Rong .

DISCOVER ONCOLOGY, 2024, 15 (01)

[34] Based on disulfidptosis, unveiling the prognostic and immunological signatures of Asian hepatocellular carcinoma and identifying the potential therapeutic target ZNF337-AS1 [J].

Shen, Duo ;

Sha, Ling ;

Yang, Ling ;

Gu, Xuefeng .

DISCOVER ONCOLOGY, 2025, 16 (01)

[35] Molecular Mechanisms of lncRNAs in the Dependent Regulation of Cancer and Their Potential Therapeutic Use [J].

Garcia-Padilla, Carlos ;

Duenas, Angel ;

Garcia-Lopez, Virginio ;

Aranega, Amelia ;

Franco, Diego ;

Garcia-Martinez, Virginio ;

Lopez-Sanchez, Carmen .

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 2022, 23 (02)

[36] Prognostic value and immune landscapes of disulfidptosis-related lncRNAs in bladder cancer [J].

Liu, Yijiang ;

Tao, Huijing ;

Jia, Shengjun ;

Wang, Haozheng ;

Guo, Long ;

Hu, Zhuozheng ;

Zhang, Wenxiong ;

Liu, Fei .

MOLECULAR AND CLINICAL ONCOLOGY, 2025, 22 (02)

[37] Regulatory effects of lncRNAs and miRNAs on the crosstalk between autophagy and EMT in cancer: a new era for cancer treatment [J].

Si, Lihui ;

Yang, Zecheng ;

Ding, Lu ;

Zhang, Duoduo .

JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY, 2022, 148 (03) :547-564

[38] Comprehensive analysis of competitive endogenous RNAs network reveals potential prognostic lncRNAs in gastric cancer [J].

Sun, Dengzhong ;

Miao, Yongzhi ;

Xu, Wu ;

Shi, Weijun ;

Wang, Lili ;

Chen, Tianwen ;

Wen, Hexin ;

Wu, Huazhang ;

Liu, Mulin .

HELIYON, 2020, 6 (05)

[39] A comprehensive evaluation of the therapeutic potential of silibinin: a ray of hope in cancer treatment [J].

Ray, Pantha Prodip ;

Islam, Mohammad Ashraful ;

Islam, Mohammad Safiqul ;

Han, Aixia ;

Geng, Peiwu ;

Aziz, Md. Abdul ;

Al Mamun, Abdullah .

FRONTIERS IN PHARMACOLOGY, 2024, 15

[40] The Application of lncRNAs in Cancer Treatment and Diagnosis [J].

Zhang, Yi ;

Tang, Liling .

RECENT PATENTS ON ANTI-CANCER DRUG DISCOVERY, 2018, 13 (03) :292-301

← 1 2 3 4 5 →