Therapeutic Potential of lncRNAs in Regulating Disulfidptosis for Cancer Treatment

被引：0

作者：

Abida ^{[1
]}

Altamimi, Abdulmalik S. A. ^{[2
]}

Ghaboura, Nehmat ^{[3
]}

Balaraman, Ashok Kumar ^{[4
]}

Rajput, Pranchal ^{[5
]}

Bansal, Pooja ^{[6
]}

Rawat, Sushama ^{[7
]}

Alanazi, Fadiyah Jadid ^{[8
,9
]}

Alruwaili, Abeer Nuwayfi ^{[10
]}

Aldhafeeri, Nouf Afit ^{[11
,12
]}

Ali, Haider ^{[13
,14
]}

Deb, Pran Kishore ^{[15
]}

机构：

[1] Northern Border Univ, Coll Pharm, Dept Pharmaceut Chem, Rafha 91911, Saudi Arabia

[2] Prince Sattam Bin Abdulaziz Univ, Coll Pharm, Dept Pharmaceut Chem, Al Kharj 11942, Saudi Arabia

[3] Batterjee Med Coll, Dept Pharm Practice, Pharm Program, POB 6231, Jeddah 21442, Saudi Arabia

[4] Univ Cyberjaya, Res & Enterprise, Cyber 11, Cyberjaya 63000, Selangor, Malaysia

[5] Chandigarh Grp Coll Jhanjeri, Chandigarh Pharm Coll, Mohali 140307, Punjab, India

[6] Vivekananda Global Univ, Dept Allied Healthcare & Sci, Jaipur 303012, Rajasthan, India

[7] Graph Era Deemed Univ, Dept Biotechnol, Bell Rd clement town, Dehra Dun, Uttarakhand, India

[8] Northern Border Univ, Coll Nursing, Publ Hlth Nursing Dept, Ar Ar, Saudi Arabia

[9] Northern Border Univ, Ctr Hlth Res, Ar Ar, Saudi Arabia

[10] Jouf Univ, Coll Nursing, Dept Nursing Adm & Educ, Al Jouf 72388, Saudi Arabia

[11] King Saud bin Abdulaziz Univ Hlth Sci, Coll Nursing, Riyadh, Saudi Arabia

[12] King Abdullah Int Med Res Ctr, Riyadh, Saudi Arabia

[13] Saveetha Univ, Saveetha Inst Med & Tech Sci, Saveetha Med Coll, Ctr Global Hlth Res, Chennai, India

[14] Dept Hosp Surg, IK Akhunbaev Kyrgyz State Med Acad, Bishkek, Kyrgyzstan

[15] Birla Inst Technol BIT, Dept Pharmaceut Sci & Technol, Ranchi 835215, Jharkhand, India

来源：

PATHOLOGY RESEARCH AND PRACTICE | 2024年 / 263卷

关键词：

Long non-coding RNA; Disulfidptosis; Cancer; Cell death; LONG NONCODING RNAS; COLON-CANCER; BREAST-CANCER; LUNG-CANCER; HEPATOCELLULAR-CARCINOMA; IMMUNOTHERAPY RESPONSES; COMPREHENSIVE ANALYSIS; PREDICTING PROGNOSIS; GASTRIC-CANCER; CELL;

D O I：

10.1016/j.prp.2024.155657

中图分类号：

R36 [病理学];

学科分类号：

100104 ;

摘要：

Non-coding RNAs (lncRNAs) play critical roles in various cellular processes, including a novel form of regulated cell death known as disulfidptosis, characterized by accumulating protein disulfide bonds and severe endoplasmic reticulum stress. This review highlights the therapeutic potential of lncRNAs in regulating disulfidptosis for cancer treatment, emphasizing their influence on key pathway components such as GPX4, SLC7A11, and PDIA family members. Recent studies have demonstrated that targeting specific lncRNAs can sensitize cancer cells to disulfidptosis, offering a promising approach to cancer therapy. The regulation of disulfidptosis by lncRNAs involves various signaling pathways, including oxidative stress, ER stress, and calcium signaling. This review also discusses the molecular mechanisms underlying lncRNA regulation of disulfidptosis, the challenges of developing lncRNA-based therapies, and the future potential of this rapidly advancing field in cancer research.

引用

页数：12

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