Therapeutic Potential of lncRNAs in Regulating Disulfidptosis for Cancer Treatment

被引:0
|
作者
Abida [1 ]
Altamimi, Abdulmalik S. A. [2 ]
Ghaboura, Nehmat [3 ]
Balaraman, Ashok Kumar [4 ]
Rajput, Pranchal [5 ]
Bansal, Pooja [6 ]
Rawat, Sushama [7 ]
Alanazi, Fadiyah Jadid [8 ,9 ]
Alruwaili, Abeer Nuwayfi [10 ]
Aldhafeeri, Nouf Afit [11 ,12 ]
Ali, Haider [13 ,14 ]
Deb, Pran Kishore [15 ]
机构
[1] Northern Border Univ, Coll Pharm, Dept Pharmaceut Chem, Rafha 91911, Saudi Arabia
[2] Prince Sattam Bin Abdulaziz Univ, Coll Pharm, Dept Pharmaceut Chem, Al Kharj 11942, Saudi Arabia
[3] Batterjee Med Coll, Dept Pharm Practice, Pharm Program, POB 6231, Jeddah 21442, Saudi Arabia
[4] Univ Cyberjaya, Res & Enterprise, Cyber 11, Cyberjaya 63000, Selangor, Malaysia
[5] Chandigarh Grp Coll Jhanjeri, Chandigarh Pharm Coll, Mohali 140307, Punjab, India
[6] Vivekananda Global Univ, Dept Allied Healthcare & Sci, Jaipur 303012, Rajasthan, India
[7] Graph Era Deemed Univ, Dept Biotechnol, Bell Rd clement town, Dehra Dun, Uttarakhand, India
[8] Northern Border Univ, Coll Nursing, Publ Hlth Nursing Dept, Ar Ar, Saudi Arabia
[9] Northern Border Univ, Ctr Hlth Res, Ar Ar, Saudi Arabia
[10] Jouf Univ, Coll Nursing, Dept Nursing Adm & Educ, Al Jouf 72388, Saudi Arabia
[11] King Saud bin Abdulaziz Univ Hlth Sci, Coll Nursing, Riyadh, Saudi Arabia
[12] King Abdullah Int Med Res Ctr, Riyadh, Saudi Arabia
[13] Saveetha Univ, Saveetha Inst Med & Tech Sci, Saveetha Med Coll, Ctr Global Hlth Res, Chennai, India
[14] Dept Hosp Surg, IK Akhunbaev Kyrgyz State Med Acad, Bishkek, Kyrgyzstan
[15] Birla Inst Technol BIT, Dept Pharmaceut Sci & Technol, Ranchi 835215, Jharkhand, India
关键词
Long non-coding RNA; Disulfidptosis; Cancer; Cell death; LONG NONCODING RNAS; COLON-CANCER; BREAST-CANCER; LUNG-CANCER; HEPATOCELLULAR-CARCINOMA; IMMUNOTHERAPY RESPONSES; COMPREHENSIVE ANALYSIS; PREDICTING PROGNOSIS; GASTRIC-CANCER; CELL;
D O I
10.1016/j.prp.2024.155657
中图分类号
R36 [病理学];
学科分类号
100104 ;
摘要
Non-coding RNAs (lncRNAs) play critical roles in various cellular processes, including a novel form of regulated cell death known as disulfidptosis, characterized by accumulating protein disulfide bonds and severe endoplasmic reticulum stress. This review highlights the therapeutic potential of lncRNAs in regulating disulfidptosis for cancer treatment, emphasizing their influence on key pathway components such as GPX4, SLC7A11, and PDIA family members. Recent studies have demonstrated that targeting specific lncRNAs can sensitize cancer cells to disulfidptosis, offering a promising approach to cancer therapy. The regulation of disulfidptosis by lncRNAs involves various signaling pathways, including oxidative stress, ER stress, and calcium signaling. This review also discusses the molecular mechanisms underlying lncRNA regulation of disulfidptosis, the challenges of developing lncRNA-based therapies, and the future potential of this rapidly advancing field in cancer research.
引用
收藏
页数:12
相关论文
共 50 条
  • [1] LncRNAs and the cancer epigenome: Mechanisms and therapeutic potential
    Nadhan, Revathy
    Isidoro, Ciro
    Song, Yong Sang
    Dhanasekaran, Danny N.
    CANCER LETTERS, 2024, 605
  • [2] Prognostic model based on disulfidptosis-related lncRNAs for predicting survival and therapeutic response in bladder cancer
    Han, Lirui
    Yang, Hankai
    Jiang, Xuan
    Zhou, Ziyu
    Ge, Chang
    Yu, Kairan
    Li, Guofang
    Wang, Wei
    Liu, Yubo
    FRONTIERS IN IMMUNOLOGY, 2024, 15
  • [3] Emerging Role and Therapeutic Potential of lncRNAs in Colorectal Cancer
    Schwarzmueller, Laura
    Bril, Oscar
    Vermeulen, Louis
    Leveille, Nicolas
    CANCERS, 2020, 12 (12) : 1 - 21
  • [4] lncRNAs: potential therapeutic targets and biomarkers for pancreatic cancer?
    Montes, Marta
    Arnes, Luis
    EXPERT OPINION ON THERAPEUTIC TARGETS, 2021, 25 (07) : 521 - 528
  • [5] Disulfidptosis-associated lncRNAs predict breast cancer subtypes
    Qing Xia
    Qibin Yan
    Zehua Wang
    Qinyuan Huang
    Xinying Zheng
    Jinze Shen
    Lihua Du
    Hanbing Li
    Shiwei Duan
    Scientific Reports, 13
  • [6] Disulfidptosis-associated lncRNAs predict breast cancer subtypes
    Xia, Qing
    Yan, Qibin
    Wang, Zehua
    Huang, Qinyuan
    Zheng, Xinying
    Shen, Jinze
    Du, Lihua
    Li, Hanbing
    Duan, Shiwei
    SCIENTIFIC REPORTS, 2023, 13 (01)
  • [7] LncRNAs and miRNAs: potential biomarkers and therapeutic targets for prostate cancer
    Ma, Guoxing
    Tang, Mingqing
    Wu, Yaqing
    Xu, Xiaoming
    Pan, Feng
    Xu, Ruian
    AMERICAN JOURNAL OF TRANSLATIONAL RESEARCH, 2016, 8 (12): : 5141 - 5150
  • [8] Exosomal lncRNAs in the Tumor Angiogenesis: As Therapeutic Targets in Cancer Treatment
    Hsu, Chou-Yi
    Altalbawy, Farag M. A.
    Oghenemaro, Enwa Felix
    Uthirapathy, Subasini
    Chandra, Muktesh
    Nathiya, Deepak
    Kaur, Parjinder
    Ravi Kumar, M.
    Kadhim, Abed J.
    Kariem, Muthena
    ARCHIV DER PHARMAZIE, 2025, 358 (04)
  • [9] Development of a disulfidptosis-related prognostic model for endometrial cancer with potential therapeutic target
    Li, Chunmei
    Fan, Xuefei
    Wang, Xue
    Yao, Yulan
    Huang, Bing
    Chen, Linlin
    Cao, Lu
    Peng, Tao
    Lin, Yingying
    Cai, Rong
    DISCOVER ONCOLOGY, 2024, 15 (01)
  • [10] Prognostic value and immune landscapes of disulfidptosis-related lncRNAs in bladder cancer
    Liu, Yijiang
    Tao, Huijing
    Jia, Shengjun
    Wang, Haozheng
    Guo, Long
    Hu, Zhuozheng
    Zhang, Wenxiong
    Liu, Fei
    MOLECULAR AND CLINICAL ONCOLOGY, 2025, 22 (02)