Photocatalytic C-H Trifluoroethoxylation of (Hetero)arenes

被引：0

作者：

Chen, Mingxi ^{[1
]}

Ling, Jingjing ^{[1
]}

Cheng, Keguang ^{[1
,2
]}

Wang, Quande ^{[1
]}

机构：

[1] Guangxi Normal Univ, Collaborat Innovat Ctr Guangxi Ethn Med, State Key Lab Chem & Mol Engn Med Resources, Key Lab Chem & Mol Engn Med Resources,Minist Educ, Guilin 541004, Peoples R China

[2] China Pharmaceut Univ, State Key Lab Nat Med, Nanjing 211198, Jiangsu, Peoples R China

来源：

ORGANIC LETTERS | 2025年 / 27卷 / 09期

关键词：

PALLADIUM-CATALYZED 2,2,2-TRIFLUOROETHOXYLATION; BOND FORMATION; ARYL; FACILE; ETHERS; ACCESS; ARENES; ACIDS;

D O I：

10.1021/acs.orglett.5c00383

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The trifluoroethoxy group (OCH2CF3) is a valuable motif prevalent in pharmaceuticals and agrichemicals. Herein, we present a simple radical trifluoroethoxylation method that enables nondirected functionalization of C-H bonds of a broad array of substrates, providing access to (hetero)aryl trifluoroethyl ethers. The current protocol tolerates a variety of synthetically and pharmacologically relevant functional groups. Applicability is also demonstrated through the late-stage functionalization of biorelevant molecules and marketing drugs.

引用

页码：2241 / 2246

页数：6

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