Photocatalytic C-H Trifluoroethoxylation of (Hetero)arenes

被引:0
|
作者
Chen, Mingxi [1 ]
Ling, Jingjing [1 ]
Cheng, Keguang [1 ,2 ]
Wang, Quande [1 ]
机构
[1] Guangxi Normal Univ, Collaborat Innovat Ctr Guangxi Ethn Med, State Key Lab Chem & Mol Engn Med Resources, Key Lab Chem & Mol Engn Med Resources,Minist Educ, Guilin 541004, Peoples R China
[2] China Pharmaceut Univ, State Key Lab Nat Med, Nanjing 211198, Jiangsu, Peoples R China
关键词
PALLADIUM-CATALYZED 2,2,2-TRIFLUOROETHOXYLATION; BOND FORMATION; ARYL; FACILE; ETHERS; ACCESS; ARENES; ACIDS;
D O I
10.1021/acs.orglett.5c00383
中图分类号
O62 [有机化学];
学科分类号
070303 ; 081704 ;
摘要
The trifluoroethoxy group (OCH2CF3) is a valuable motif prevalent in pharmaceuticals and agrichemicals. Herein, we present a simple radical trifluoroethoxylation method that enables nondirected functionalization of C-H bonds of a broad array of substrates, providing access to (hetero)aryl trifluoroethyl ethers. The current protocol tolerates a variety of synthetically and pharmacologically relevant functional groups. Applicability is also demonstrated through the late-stage functionalization of biorelevant molecules and marketing drugs.
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收藏
页码:2241 / 2246
页数:6
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